2,3,4,6-Tetra-O-acetyl-α-D-galactopyranosyl 2,2,2-trichloroacetimidate CAS:86520-63-0

2,3,4,6-Tetra-O-acetyl-α-D-galactopyranosyl 2,2,2-trichloroacetimidate ndi mankhwala omwe amagwiritsidwa ntchito kwambiri mu carbohydrate chemistry ndi glycosylation reactions. Ndi chinthu chochokera ku α-D-galactopyranose, mtundu wa shuga, komwe magulu a hydroxyl omwe ali pamalo a 2, 3, 4, ndi 6 a galactopyranose ring amakhala acetylated. Kuphatikiza apo, anomeric carbon (C1) ya shuga imatetezedwa ndi gulu la trichloroacetimidate, zomwe zimapangitsa kuti ikhale electrophile yamphamvu panthawi ya glycosylation reactions.

Kawirikawiri mankhwalawa amagwiritsidwa ntchito ngati glycosylating agent kuti alowetse ma galactose moieties m'mamolekyu osiyanasiyana, monga mapuloteni, ma peptide, kapena mamolekyu ang'onoang'ono achilengedwe. Izi zitha kuchitika pochita izi ndi nucleophile (monga magulu a hydroxyl pa molekyulu yomwe mukufuna) pansi pa mikhalidwe yoyenera. Gulu la trichloroacetimidate limathandizira kuti galactose moiety igwirizane ndi molekyulu yomwe mukufuna, zomwe zimapangitsa kuti pakhale glycosidic bond.

Mankhwalawa amagwiritsidwa ntchito kwambiri popanga ma glycoconjugates, ma glycopeptides, ndi ma glycolipids. Amapereka njira yosinthasintha komanso yothandiza yosinthira mamolekyu okhala ndi zotsalira za galactose, zomwe zingakhale zofunikira m'magawo osiyanasiyana, kuphatikiza maphunziro a zamoyo, njira zoperekera mankhwala, kapena kupanga katemera.

Oda kapena Pemphani Mtengo

Tsatanetsatane wa Zamalonda

Ma tag a Zamalonda

Kugwiritsa Ntchito ndi Zotsatira zake

Glycosylation: Chosakanizachi chimagwira ntchito ndi mamolekyu osiyanasiyana a acceptor okhala ndi magulu a hydroxyl, monga ma alcohols kapena amines, kuti apange ma glycosidic bond. Izi zimathandiza kuti galactose ilowe mu molekyulu ya acceptor, zomwe zimapangitsa kuti ma glycoconjugates, ma glycopeptides, kapena ma glycolipids apangidwe.

Maphunziro a zamoyo ndi zamoyo: Chosakanizachi chimathandiza ofufuza kuphunzira ntchito zamoyo ndi momwe mamolekyu okhala ndi galactose amagwirira ntchito. Mwa kuphatikiza galactose ndi mapuloteni, ma peptide, kapena ma biomolecule ena, ofufuza amatha kufufuza ntchito zawo mu njira zamaselo, momwe ma receptor-ligand amagwirira ntchito, komanso njira zochizira matenda.

Njira zoperekera mankhwala: Chosakanizachi chingagwiritsidwe ntchito kusintha mamolekyu a mankhwala okhala ndi zotsalira za galactose, zomwe zimathandiza kuti mankhwalawo aperekedwe ku minofu kapena maselo enaake. Galactose imatha kugwira ntchito ngati ligand yowunikira, kuzindikira ma receptors enaake omwe amapezeka pamwamba pa maselo, makamaka ma hepatocytes. Mwa kuphatikiza galactose ndi mankhwala, ofufuza amatha kuwonjezera kusankha kwawo komanso kugwira ntchito bwino pochiza matenda omwe akuyang'aniridwa.

Kupanga katemera: Mamolekyu okhala ndi galactose amachita gawo lofunika kwambiri pakuyankha kwa chitetezo chamthupi, chifukwa amadziwika ndi ma lectin omwe amapezeka m'maselo a chitetezo chamthupi. Mwa kuphatikiza ma antigen ndi ma galactose pogwiritsa ntchito mankhwalawa, ofufuza amatha kuwonjezera mayankho a chitetezo chamthupi ndikupanga katemera wogwira mtima kwambiri.

Kupanga mankhwala: Chosakanizachi chingagwiritsidwe ntchito popanga mankhwala osiyanasiyana komwe kumafunika kusintha kwa galactose. Izi zikuphatikizapo kukonzekera kapangidwe ka chakudya chovuta, oligosaccharides, kapena glycomimetics, zomwe zingagwiritsidwenso ntchito mu mankhwala kapena ngati zida zofufuzira.

Chitsanzo cha Zamalonda

Kulongedza Zinthu:

Zina Zowonjezera:

Kapangidwe kake	C16H20Cl3NO10
Kuyesa	99%
Maonekedwe	Ufa woyera
Nambala ya CAS	86520-63-0
Kulongedza	Kakang'ono komanso kochuluka
Moyo wa Shelufu	zaka 2
Malo Osungirako	Sungani pamalo ozizira komanso ouma
Chitsimikizo	ISO.