β-Nicotinamide Adenine Dinucleotide CAS:53-84-9

NAD+ ndi yofunika kwambiri pa ntchito ya maselo ndipo yapeza chidwi m'magawo monga kafukufuku wa ukalamba, kagayidwe kachakudya, ndi thanzi la maselo. Monga coenzyme, NAD+ imagwira ntchito mu redox reactions yofunikira popanga mphamvu mkati mwa mitochondria, kuthandizira njira monga glycolysis, tricarboxylic acid cycle, ndi oxidative phosphorylation. Kuphatikiza apo, NAD+ imagwira ntchito ngati gawo la ma enzyme monga sirtuins ndi PARPs, omwe amagwira ntchito pakukonzanso DNA, kuwongolera mawonekedwe a majini, komanso njira zoyankhira kupsinjika kwa maselo. M'zaka zaposachedwa, zinthu zoyambira za NAD+, monga nicotinamide riboside (NR) ndi nicotinamide mononucleotide (NMN), zatchuka ngati zowonjezera zomwe zingathandize milingo ya NAD+ mkati mwa maselo. Kafukufuku akusonyeza kuti kusunga milingo yabwino kwambiri ya NAD+ kungathandize pa biogenesis ya mitochondrial, metabolic homeostasis, ndi moyo wautali. Chifukwa chake, zinthu zoyambira za NAD+ zikufufuzidwa kuti zithetse kuchepa kwa ukalamba, kuthandizira ukalamba wathanzi, komanso kuthana ndi kusalingana kwa kagayidwe kachakudya komwe kumakhudzana ndi matenda monga kunenepa kwambiri ndi matenda ashuga. Kuphatikiza apo, NAD+ ndi gawo lomwe likukulirakulira chidwi cha masewera ndi fizikiki ya masewera olimbitsa thupi chifukwa cha kutenga nawo mbali mu kagayidwe ka mphamvu ndi ntchito ya mitochondrial. Maphunziro ofufuza kusintha kwa NAD+ pokhudzana ndi magwiridwe antchito olimbitsa thupi, kuchira kwa minofu, ndi mphamvu yopirira akupitilira, zomwe zingakhudze magwiridwe antchito amasewera komanso kulimba mtima. Ponseponse, NAD+ ndi zinthu zomwe zimatsogolera zake zikuyimira gawo lofufuza lasayansi lomwe lingagwiritsidwe ntchito pofufuza ukalamba, thanzi la maselo, kagayidwe kachakudya, ndi fizikiki ya masewera olimbitsa thupi, zomwe zikusonyeza kuti kafukufuku ndi wofunikira kwambiri pakuchiritsa.