Acetylcholinesterase CAS:9000-81-1

Mankhwala oletsa kutsekeka kwa mitsempha ndi gulu la mankhwala kapena mankhwala omwe amaletsa kugwira ntchito kwa enzyme ya acetylcholinesterase. Acetylcholinesterase imayambitsa kuphwanya acetylcholine ya neurotransmitter m'thupi. Mwa kuletsa enzyme iyi, mankhwala oletsa kutsekeka kwa mitsempha amawonjezera kuchuluka kwa acetylcholine, zomwe zimapangitsa kuti ntchito ya cholinergic ichuluke m'mitsempha yapakati ndi ya m'mphepete mwa mitsempha ikule.

Kugwiritsa ntchito kwakukulu kwa mankhwala oletsa cholinesterases pochiza matenda amitsempha monga matenda a Alzheimer's ndi myasthenia gravis. Mu matenda a Alzheimer's, mankhwala awa cholinga chake ndi kupititsa patsogolo kufalikira kwa mitsempha ya cholinergic ndikuchepetsa kuchepa kwa chidziwitso. Mu myasthenia gravis, mankhwala oletsa cholinesterases amathandiza kupititsa patsogolo kufalikira kwa mitsempha ya mitsempha ndi mphamvu ya minofu.

Ntchito zina za anticholinesterases ndi monga kuzindikira ndi kuchiza poizoni wa anticholinergic, makamaka kuchokera ku mankhwala ena ophera tizilombo kapena mankhwala a mitsempha. Zinthuzi zimatha kuyambitsa kukondoweza kwambiri kwa ma muscarinic ndi nicotinic receptors, zomwe zimapangitsa kuti zizindikiro monga kufooka kwa minofu, kunjenjemera, komanso kupuma movutikira. Anticholinesterases amatha kusintha izi mwa kuwonjezera kuchuluka kwa acetylcholine ndikupikisana ndi zinthu zapoizoni.

Oda kapena Pemphani Mtengo

Tsatanetsatane wa Zamalonda

Ma tag a Zamalonda

Kugwiritsa Ntchito ndi Zotsatira zake

Mphamvu ya anticholinesterase imatanthauza kuthekera kwa mankhwala ena kapena mankhwala kuletsa ntchito ya enzyme ya acetylcholinesterase. Acetylcholinesterase imayambitsa kuphwanya acetylcholine ya neurotransmitter m'thupi. Mwa kuletsa enzyme iyi, anticholinesterases imawonjezera kuchuluka kwa acetylcholine, zomwe zimapangitsa kuti ntchito ya cholinergic ichuluke.

Kugwiritsa ntchito kwakukulu kwa mankhwala oletsa cholinesterases ndi pochiza matenda omwe amadziwika ndi kuchepa kwa ntchito ya cholinergic. Izi zikuphatikizapo matenda amitsempha monga matenda a Alzheimer's ndi myasthenia gravis. Mu matenda a Alzheimer's, mankhwala oletsa cholinesterases monga donepezil, rivastigmine, ndi galantamine amagwiritsidwa ntchito poletsa kusweka kwa acetylcholine ndikuwonjezera kufalikira kwa cholinergic neurotransmission. Izi zingathandize kukonza magwiridwe antchito a ubongo ndikuchepetsa kupitirira kwa matendawa.

Mu matenda a myasthenia gravis, mankhwala oletsa cholinesterase monga neostigmine ndi pyridostigmine amagwiritsidwa ntchito popititsa patsogolo kufalikira kwa mitsempha ya m'mitsempha. Mankhwalawa amaletsa acetylcholinesterase ndikuwonjezera kuchuluka kwa acetylcholine pamalo olumikizirana mitsempha ya m'mitsempha, kulimbitsa mphamvu ya minofu ndikuchepetsa kufooka kwa minofu.

Mankhwala oletsa cholinesterase amakhalanso ndi ntchito zodziwira matenda komanso zochiritsira pakakhala poizoni wa cholinergic. Mankhwala oletsa cholinesterase, monga mankhwala ena ophera tizilombo kapena mankhwala a mitsempha, angayambitse kutsekeka kwakukulu kwa cholinergic komwe kumabweretsa zizindikiro monga chisokonezo, kugunda kwa mtima mofulumira, pakamwa pouma, komanso kusawona bwino. M'mikhalidwe yotereyi, mankhwala oletsa cholinesterase monga pralidoxime angagwiritsidwe ntchito kusintha zotsatira zake powonjezera kuchuluka kwa acetylcholine ndikupikisana ndi zinthu zapoizoni.

Kulongedza Zinthu:

Zina Zowonjezera:

Kapangidwe kake	N / A
Kuyesa	99%
Maonekedwe	Ufa wachikasu wopepuka
Nambala ya CAS	9000-81-1
Kulongedza	Kakang'ono komanso kochuluka
Moyo wa Shelufu	zaka 2
Malo Osungirako	Sungani pamalo ozizira komanso ouma
Chitsimikizo	ISO.