Acetylthiocholine iodide CAS:1866-15-5

Acetylthiocholine iodide imagwiritsidwa ntchito makamaka ngati gawo loyezera ntchito ya enzyme acetylcholinesterase (AChE). AChE imayambitsa kuswa kwa acetylcholine ya neurotransmitter mu dongosolo lamanjenje. Kuwonjezera kwa acetylthiocholine iodide ku chisakanizo cha reaction chokhala ndi AChE kumapangitsa kuti thiocholine ndi acetate zipangidwe.

Kachitidwe kameneka kangathe kuzindikirika powonjezera chizindikiro cha colorimetric kapena fluorometric chomwe chimayanjanitsidwa makamaka ndi thiocholine. Kuchuluka kwa mtundu kapena kupanga kwa fluorescence kumagwirizana mwachindunji ndi ntchito ya AChE mu chitsanzo. Izi zimapangitsa acetylthiocholine iodide kukhala chida chofunikira poyezera ntchito ya AChE m'masampulu osiyanasiyana a zamoyo, kuphatikizapo minofu, ma cell cultures, ndi magazi.

Kuyeza ntchito ya AChE pogwiritsa ntchito acetylthiocholine iodide kumagwiritsidwa ntchito kwambiri mu kafukufuku wokhudzana ndi machitidwe a cholinergic, matenda a neurodegenerative, komanso kupezeka kwa mankhwala ena kapena mankhwala omwe angakhudze ntchito ya AChE. Ingagwiritsidwenso ntchito ngati chida chowunikira kuti mupeze zoletsa za AChE, zomwe ndizofunikira pakupanga mankhwala a matenda monga Alzheimer's ndi Parkinson's.

Kuwonjezera pa kugwiritsidwa ntchito poyesa ma enzyme, acetylthiocholine iodide ingagwiritsidwenso ntchito ngati gawo la ma biosensor ozikidwa pa AChE. Ma biosensor awa adapangidwa kuti azindikire ndikuwerengera kupezeka kwa zinthu zina zomwe zingalepheretse ntchito ya AChE, monga mankhwala ophera tizilombo a organophosphate kapena othandizira mitsempha.