Amphotericin B – jekeseni CAS:1397-89-3

Jakisoni wa Amphotericin B umagwiritsidwa ntchito pochiza matenda akuluakulu a bowa monga candidemia, invasive aspergillosis, cryptococcal meningitis, ndi mucormycosis, makamaka kwa odwala omwe ali ndi chitetezo chamthupi chofooka kapena omwe ali ndi chitetezo chamthupi chofooka. Chifukwa cha mphamvu yake yolimbana ndi bowa, jakisoni wa amphotericin B nthawi zambiri amaonedwa ngati njira yoyamba yothandizira matenda oopsa a bowa. Akatswiri azaumoyo amapereka amphotericin B kudzera m'mitsempha, akuyang'anira odwala mosamala panthawi yothira kuti athetse mavuto omwe angakhalepo, kuphatikizapo malungo, kuzizira, ndi zotsatira zokhudzana ndi kuthira. Mlingo ndi nthawi ya chithandizo cha amphotericin B zimapangidwa molingana ndi matenda enieni a bowa, matenda a wodwalayo, komanso vuto lililonse la ziwalo. Popeza ndi poizoni wa nephrotoxic komanso kuthekera kwa kusokonezeka kwa electrolyte, kuyang'anira bwino ntchito ya impso ndi kuchuluka kwa electrolyte ndikofunikira kwambiri panthawi ya chithandizo cha amphotericin B. Mapangidwe a lipid a amphotericin B angagwiritsidwe ntchito kuchepetsa poizoni wa impso ndi zotsatira zokhudzana ndi kuthira zomwe zimagwirizanitsidwa ndi amphotericin B deoxycholate wamba. Kuyang'anira nthawi zonse zotsatirapo zoyipa, monga kulephera kwa impso ndi hypokalemia, pamodzi ndi chisamaliro choyenera chothandizira, kumathandiza kuyang'anira chitetezo ndi kulekerera kwa chithandizo cha amphotericin B. Ogwira ntchito zachipatala amaganizira mosamala ubwino wa chithandizo poyerekeza ndi zoopsa zomwe zingachitike, kuonetsetsa kuti odwala alandira chithandizo choyenera cha bowa komanso kuchepetsa zotsatirapo zoyipa. Mwa kuthana bwino ndi matenda oopsa a bowa, jakisoni wa amphotericin B umagwira ntchito yofunika kwambiri pothana ndi matenda oopsa komanso kupereka njira zothandizira odwala omwe akukumana ndi matenda ovuta a bowa.