Ansamycin CAS: 72559-06-9

Ma ansamycin, monga rifamycins, amagwiritsidwa ntchito kwambiri m'machipatala pochiza matenda osiyanasiyana a bakiteriya, kuphatikizapo chifuwa chachikulu, khate, ndi mitundu ina ya matenda a staphylococcal ndi streptococcal. Rifampin, rifamycin yodziwika bwino, nthawi zambiri imagwiritsidwa ntchito ngati gawo la mankhwala ophatikizana a chifuwa chachikulu ndi matenda ena a mycobacterial. Kagwiridwe ka ntchito ka ansamycins kumaphatikizapo kumangirira ku RNA polymerase ya bakiteriya, motero kuletsa kulembedwa kwa mankhwala ndipo pamapeto pake kumabweretsa imfa ya maselo a bakiteriya. Njira yapaderayi yogwirira ntchito imapangitsa ansamycins kukhala yogwira ntchito motsutsana ndi mabakiteriya osiyanasiyana a Gram-positive ndi Gram-negative. Ogwira ntchito zachipatala amaganizira mosamala zinthu monga mtundu wa matenda, mbiri yachipatala ya wodwala, ndi zotsatira zoyezetsa za bakiteriya akamapereka ma ansamycins. Mlingo woyenera, nthawi ya chithandizo, ndi kuyang'anira zotsatirapo zake ndizofunikira kwambiri kuti muwonjezere phindu la chithandizo pomwe mumachepetsa zoopsa zokhudzana ndi kugwiritsa ntchito maantibayotiki. Zotsatira zoyipa zokhudzana ndi ansamycins zitha kuphatikizapo kusokonezeka kwa m'mimba, poizoni wa chiwindi, komanso kukhudzidwa kwa hypersensitivity. Kuyang'anira nthawi zonse mayeso a chiwindi ndi kuyang'anitsitsa zizindikiro zilizonse za zotsatira zoyipa kumathandiza kuonetsetsa kuti ansamycins akugwiritsidwa ntchito bwino komanso moyenera pochiza matenda a bakiteriya. Kawirikawiri, ansamycins ndi gulu lofunika la maantibayotiki omwe amagwiritsidwa ntchito mosiyanasiyana pochiza matenda a bakiteriya. Pogwiritsa ntchito bwino komanso kuyang'anira, akatswiri azaumoyo amatha kugwiritsa ntchito mphamvu zotsutsana ndi mabakiteriya za ansamycins kuti athane ndi matenda moyenera ndikuwonjezera zotsatira za odwala.