Boc-Ile-ONp CAS:16948-38-2

Boc-Ile-ONp imagwiritsidwa ntchito kwambiri mu njira zolumikizirana ndi ma peptide. Mu kupanga ma peptide, zimathandiza kuti ma isoleucine residues alowe m'malo mwa ma peptide, zomwe zimathandiza kuti magulu osiyanasiyana ogwira ntchito, zilembo, kapena mamolekyu agwiritsidwe ntchito mosiyanasiyana azigwirizana. Kusintha kumeneku kumalola kupanga ma peptide ambiri omwe ali ndi zinthu zomwe zimapangidwa, monga kukhazikika bwino, kulunjika kwa cholinga, kapena luso lojambula zithunzi. Mu kafukufuku wa ma proteomics, Boc-Ile-ONp imalola kulemba mapuloteni ndi ma peptides pamalo enaake, zomwe zimathandiza kusanthula kapangidwe kake, maphunziro okhudza kuyanjana, ndi kuyesa kochokera ku mass spectrometry. Kulumikizana kolamulidwa kwa Boc-Ile-ONp ku ma isoleucine residues kumathandiza kufotokoza bwino momwe mapuloteni ndi ma peptides amagwirira ntchito, kuthandizira kupita patsogolo kumvetsetsa machitidwe a zamoyo ndi njira zochizira matenda. Kuphatikiza apo, pakupanga mankhwala, Boc-Ile-ONp imagwira ntchito yofunika kwambiri pogwirizanitsa mankhwala ochiritsira ndi ma peptide kapena mapuloteni, kupanga machitidwe operekera mankhwala ofunikira, ma antibody-drug conjugates, kapena mapangidwe a katemera okhala ndi mbiri yabwino ya pharmacokinetic komanso kuchepetsa zotsatira zomwe sizili pa cholinga. Ponseponse, kudalirika ndi kusinthasintha kwa Boc-Ile-ONp pakusintha kwa peptide ndi bioconjugation zimapangitsa kuti ikhale chida chofunikira kwambiri pakupititsa patsogolo kafukufuku wokhudza kupeza mankhwala, biology ya mankhwala, ndi proteomics, zomwe zimapereka mwayi wosiyanasiyana wopanga mapulogalamu atsopano a biomedical.