dUMP, 2′-Deoxyuridine-5′-monophosphate, mchere wa disodium CAS:42155-08-8

2′-Deoxyuridine-5′-monophosphate (dUMP) ndi chinthu chochokera ku nucleotide chomwe chimagwira ntchito popanga ndi kukonza DNA. Chimagwira ntchito ngati choyambira cha dTTP (deoxythymidine triphosphate), chomwe ndi chinthu chofunikira kwambiri pakubwerezabwereza kwa DNA. dUMP ndi gawo lofunikira kwambiri pakupanga thymidylate, komwe imasinthidwa kukhala dTMP (deoxythymidine monophosphate) ndi enzyme ya thymidylate synthase. Kusintha kumeneku ndikofunikira kuti pakhale mgwirizano woyenera wa nucleotide ndi umphumphu wa DNA mkati mwa maselo.

Oda kapena Pemphani Mtengo

Tsatanetsatane wa Zamalonda

Ma tag a Zamalonda

Kugwiritsa Ntchito ndi Zotsatira zake

Kupanga DNA: dUMP imagwira ntchito ngati choyambira cha deoxythymidine triphosphate (dTTP), yomwe ndi yofunika kwambiri pakubwerezabwereza kwa DNA. Kusintha kwa dUMP kukhala dTMP ndi gawo lofunika kwambiri pakupanga ma nucleotide a thymidine, omwe ndi ofunikira kwambiri pakubwerezabwereza kolondola kwa zinthu za majini panthawi yogawa maselo.

Kupanga kwa Thymidylate: dUMP ndi gawo la enzyme ya thymidylate synthase, yomwe imasintha kusintha kwa dUMP kukhala dTMP. Njirayi ndi yofunika kwambiri pakusunga bwino nucleotide m'maselo ndikuwonetsetsa kuti DNA ikubwerezabwereza bwino.

Cholinga cha Mankhwala Oletsa Khansa: Thymidylate synthase, enzyme yomwe imagwira ntchito posintha dUMP kukhala dTMP, ndi cholinga cha mankhwala ena oletsa khansa. Kuletsa thymidylate synthase kungasokoneze kapangidwe ka DNA ndi kuchulukana kwa maselo, zomwe zimapangitsa kuti ikhale cholinga cha chemotherapy.

Chida Chofufuzira: dUMP imagwiritsidwa ntchito mu kafukufuku wa biochemical ndi molecular biology ngati substrate yophunzirira njira zopangira, kukonza, ndi kagayidwe ka DNA. Imagwiritsidwanso ntchito mu enzyme assays kuti ifufuze momwe thymidylate synthase imagwirira ntchito ndi ma enzyme ena ofanana nawo.

Kulongedza Zinthu:

Zina Zowonjezera:

Kapangidwe kake	C9H14N2NaO8P
Kuyesa	99%
Maonekedwe	Ufa woyera
Nambala ya CAS	42155-08-8
Kulongedza	Kakang'ono komanso kochuluka
Moyo wa Shelufu	zaka 2
Malo Osungirako	Sungani pamalo ozizira komanso ouma
Chitsimikizo	ISO.