Empagliflozin CAS:864070-44-0 Wopanga Wogulitsa

Empagliflozin ndi mankhwala atsopano, amphamvu komanso osankha a SGLT-2, omwe amathandiza kuwongolera shuga m'magazi komanso kukhala ndi zizindikiro za matenda a kagayidwe kachakudya m'makoswe a shuga. Empagliflozin (dzina la malonda Jardiance) ndi mankhwala oletsa shuga wa sodium glucose co-transporter-2 (SGLT-2), ndipo amachititsa kuti shuga m'magazi atulutsidwe ndi impso ndikuchotsedwa mu mkodzo. Empagliflozin ingayambitse kutaya madzi m'thupi ndikupangitsa kuti kuthamanga kwa magazi kuchepe, zomwe zimapangitsa kuti odwala azimva chizungulire kapena kukomoka komanso kuchepa kwa ntchito ya impso. Chiwopsezo cha odwala okalamba, makamaka omwe ali ndi vuto la impso komanso diuretic, chikuwoneka kuti ndi chachikulu. FDA imafuna Boehring ndi Eli Lilly kuti achite maphunziro anayi pambuyo pa malonda: mayeso omaliza a zotsatira za mtima ndi mitsempha yamagazi, mayeso a pharmacokinetics ya ana ndi pharmacodynamics, mayeso achitetezo ndi mphamvu ya ana, mayeso a poizoni wa mankhwalawa (makamaka zotsatira za ntchito ya impso, mafupa ndi kukula ndi chitukuko).