Fmoc-Arg(pbf)-OH CAS:154445-77-9

Fmoc-Arg(pbf)-OH imagwira ntchito yofunika kwambiri popanga ma peptide, makamaka pazochitika zomwe zimafuna chitetezo cholamulidwa cha nayitrogeni ya guanidine mu arginine. Gulu loteteza la Fmoc limateteza gulu la amino, ndikupangitsa kuti zochita zisankhidwe panthawi yolumikizana kwa peptide, pomwe gulu la pbf pa nayitrogeni ya guanidine limapereka chitetezo china. Ofufuza amagwiritsa ntchito Fmoc-Arg(pbf)-OH popanga ma peptide ndi kusintha kwina kwa guanidine, zomwe zimakhudza zochita zawo zamoyo. Njira yotetezera iwiri imalola kusintha molondola kwa reactivity ya guanidine, zomwe zimapangitsa kuti mankhwalawa akhale ofunika pakupanga ndi kupanga ma peptide pa maphunziro opha tizilombo toyambitsa matenda, bioconjugation, ndi mankhwala. Kugwirizana kwa Fmoc-Arg(pbf)-OH ndi njira zodziwika bwino zopangira ma peptide, kuphatikiza solid-phase peptide synthesis (SPPS), kumawonjezera ntchito yake. Phatikiziyi imagwiritsidwa ntchito popanga ma peptide pa mayeso achilengedwe, kupeza mankhwala, komanso kupanga zinthu zopangidwa ndi peptide. Kuchotsa magulu oteteza kolamulidwa kumalola kuti arginine iphatikizidwe bwino ndi guanidine yosinthidwa, zomwe zimathandiza kuti ma peptide osiyanasiyana apangidwe. Mwachidule, Fmoc-Arg(pbf)-OH ndi chida chapadera komanso chosiyanasiyana mu peptide chemistry, chomwe chimapatsa mphamvu ofufuza kuti afufuze ndikusintha momwe guanidine imagwirira ntchito pazasayansi ndi machiritso osiyanasiyana.