Fmoc-Asp(OBut)-OSu CAS:78553-23-8

Fmoc-Asp(OBut)-OSu imagwira ntchito ngati chida chosiyanasiyana popanga ma peptide, makamaka popanga ma peptide okhala ndi aspartic acid molondola. Gulu loteteza la Fmoc limateteza gulu la amino, kuonetsetsa kuti pali zochita zosiyanasiyana panthawi yolumikizana ndi peptide, pomwe gulu la O-butyl limawonjezera chitetezo china ku gulu la carboxyl. Ntchito ya OSu ester imathandizira kupanga bwino komanso kusankha ma amide bond panthawi yolumikizana ndi peptide. Ofufuza amagwiritsa ntchito kwambiri Fmoc-Asp(OBut)-OSu popanga ma peptide osiyanasiyana, kuphatikiza kupanga mankhwala, zinthu zachilengedwe, komanso kupanga ma peptide ogwira ntchito omwe ali ndi mawonekedwe apadera. Kugwirizana kwake ndi njira zodziwika bwino zopangira ma peptide, mu njira zonse zokhazikika komanso zothetsera mavuto, kumawonjezera kusinthasintha kwake muzochita zosiyanasiyana zofufuzira. Kuchotsa magulu oteteza kumalola kuphatikiza aspartic acid m'ma peptide, kukulitsa mitundu ya ma peptide opangidwa. Kuphatikiza apo, Fmoc-Asp(OBut)-OSu imagwiritsa ntchito popanga ma peptide ofufuza ma proteomics ndikuphunzira njira zama cell. Kugwiritsa ntchito bwino gulu loteteza la O-butyl kumathandiza kusintha molondola momwe aspartic acid imagwirira ntchito, ndipo gulu la OSu ester limathandizira kupanga ma peptides ndi kulemba zilembo zawo. Mwachidule, Fmoc-Asp(OBut)-OSu ndi chida chofunikira komanso chofunikira kwambiri mu peptide chemistry, chomwe chimapatsa mphamvu ofufuza kuti afufuze ndikusintha momwe aspartic acid imagwirira ntchito pazambiri zasayansi, makamaka kuyang'ana kwambiri ma peptides omwe ali ndi magwiridwe antchito abwino kudzera mu gulu la OSu ester.