Linezolid CAS:165800-03-3

Linezolid imagwiritsidwa ntchito kwambiri m'machitidwe azachipatala pochiza matenda oopsa a mabakiteriya omwe ali ndi Gram-positive omwe sagonjetsedwa ndi maantibayotiki ena. Nthawi zambiri imaperekedwa pa matenda a pakhungu ndi minofu yofewa, chibayo, bacteremia, ndi matenda a mafupa omwe amayamba chifukwa cha MRSA, VRE, ndi matenda ena osagwiritsidwa ntchito ndi mankhwala ambiri. Kutha kwa Linezolid kuthana ndi tizilombo toyambitsa matenda tovuta kuchiza kumapangitsa kuti ikhale mankhwala ofunikira kwambiri polimbana ndi matenda ovuta. M'zipatala, linezolid nthawi zambiri imagwiritsidwa ntchito pochiza matenda a nosocomial ndi chibayo chokhudzana ndi chisamaliro chaumoyo chifukwa cha ntchito yake yayikulu komanso chitetezo chabwino. Mankhwala ake opangidwa pakamwa amalola kuti odwala ena azilandira chithandizo chosavuta, kupatsa odwala chithandizo chogwira mtima motsutsana ndi mabakiteriya omwe ali ndi vuto. Kuphatikiza apo, linezolid imagwiritsidwa ntchito pochiza chifuwa chachikulu ndi matenda ena a mycobacterial monga gawo la mankhwala ophatikizana. Njira yake yapadera yogwirira ntchito komanso kulowa bwino kwa minofu kumapangitsa kuti ikhale yowonjezera pa armamentarium yochizira chifuwa chachikulu chosagwirizana ndi mankhwala komanso matenda a mycobacterial omwe si a chifuwa chachikulu. M'malo ofufuza, linezolid imagwiritsidwa ntchito ngati muyezo wofunikira poyesa kukana maantibayotiki kuti awone ngati mabakiteriya amakhudzidwa ndi maantibayotiki awa. Mwa kudziwa kuchuluka kwa mankhwala oletsa kufalikira kwa mabakiteriya (MIC) omwe amaletsa kugwiritsa ntchito mankhwala (MIC) motsutsana ndi mabakiteriya enaake, ofufuza amatha kutsogolera njira zoyenera zochizira ndikuwunika momwe mankhwalawo amakanira. Ponseponse, linezolid imagwira ntchito yofunika kwambiri pochiza matenda opatsirana omwe ali ndi Gram-positive bacteria, zomwe zimapatsa madokotala njira yodalirika komanso yothandiza yochizira matenda opatsirana omwe sagonjetsedwa ndi mankhwala. Chifukwa cha mphamvu zake zodziwika bwino, kulekerera kwake, komanso kusinthasintha kwake, zimapangitsa kuti ikhale gawo lofunika kwambiri polimbana ndi matenda opatsirana, makamaka omwe amayamba chifukwa cha mabakiteriya omwe sagonjetsedwa ndi mankhwala ambiri.