N-methyl-2,2,2-trifluoroacetamide CAS:815-06-5

N-Ethyl 2-methyl-4,4,4-trifluoroacetoacetate (EMTFA) imadziwika ndi kapangidwe kake ka molekyulu, komwe kumaphatikizapo gulu la trifluoromethyl (-CF3) lolumikizidwa ku msana wa β-keto ester. Kapangidwe kameneka kamapereka kukhazikika kwakukulu ndi kuchitapo kanthu ku EMTFA, zomwe zimapangitsa kuti ikhale yoyenera kugwiritsidwa ntchito m'mankhwala osiyanasiyana. EMTFA nthawi zambiri imakhala ngati madzi owoneka bwino, opanda mtundu wokhala ndi kutentha kozungulira 140°C ndipo imawonetsa kusungunuka bwino mu zosungunulira zachilengedwe monga acetone ndi ethyl acetate. Kukhazikika kwake pansi pa mikhalidwe yosiyanasiyana kumalola kuti igwiritsidwe ntchito bwino mu kafukufuku wa labotale komanso m'mafakitale. Kugwiritsa Ntchito Kapangidwe ka Zachilengedwe: EMTFA imagwira ntchito yofunika kwambiri popanga zinthu zachilengedwe, makamaka pakulowetsa ma motifs a trifluoromethylated mu mamolekyulu achilengedwe. Kuthekera kumeneku ndikofunikira popanga mankhwala, mankhwala a agrochemicals, ndi mankhwala apadera omwe ali ndi ntchito yowonjezera ya zamoyo komanso kukhazikika kwa mankhwala. Mankhwala a Mankhwala: Mu ntchito zamankhwala, EMTFA imagwiritsidwa ntchito ngati choyambira popanga zosakaniza zogwira ntchito zamankhwala (APIs) chifukwa cha kuthekera kwake kupereka zinthu zabwino zamankhwala. Imagwira ntchito yofunika kwambiri mu mankhwala a chemistry polola kusintha kwa mamolekyulu a mankhwala kuti awonjezere kugwira ntchito bwino ndikuchepetsa chiopsezo cha kagayidwe kachakudya. Mankhwala Apadera: EMTFA imagwiritsa ntchito popanga mankhwala apadera monga mankhwala ophera udzu, mankhwala ophera tizilombo, ndi zinthu zina zovuta zomwe zimagwiritsidwa ntchito popanga mankhwala a agrochemicals ndi mankhwala abwino. Kusinthasintha kwake pakusintha kwa mankhwala kumapangitsa kuti ikhale yofunikira popanga mankhwala komwe kumafunika kuwongolera molondola kapangidwe ka mamolekyulu ndi magwiridwe antchito. Kupanga Ethyl 2-methyl-4,4,4-trifluoroacetoacetate kumapangidwa kudzera mu njira ya masitepe ambiri kuyambira ndi Claisen condensation reaction ya ethyl trifluoroacetate ndi methyl acetate, kutsatiridwa ndi esterification pansi pa mikhalidwe yolamulidwa. Kuchitapo kanthu nthawi zambiri kumachitika pamaso pa chothandizira choyambira kuti chithandizire kupanga β-keto ester. Njira zoyeretsera monga distillation kapena recrystallization zimagwiritsidwa ntchito kuti EMTFA ikhale yoyera kwambiri yoyenera kugwiritsidwa ntchito m'mafakitale. Njira yosavuta yopangira komanso kupezeka kwa zinthu zoyambira zimathandiza kuti ikhale yotsika mtengo komanso yogwiritsidwa ntchito kwambiri mu kafukufuku wamaphunziro ndi njira zamafakitale. Mwachidule, ethyl 2-methyl-4,4,4-trifluoroacetoacetate ndi mankhwala ogwiritsidwa ntchito mosiyanasiyana omwe amagwiritsidwa ntchito kwambiri popanga zinthu zachilengedwe, kupanga mankhwala, komanso kupanga mankhwala apadera. Makhalidwe ake apadera a mankhwala, kuphatikizapo kukhazikika, kuchitapo kanthu, komanso kusavuta kupanga, amaika chinthu chofunikira kwambiri pakupititsa patsogolo ukadaulo m'magawo osiyanasiyana amafakitale ndi m'magawo asayansi.