Natamycin/Pimaricin CAS: 7681-93-8 Wopanga Wopanga Chithunzi Chodziwika

Natamycin/Pimaricin CAS: 7681-93-8 Wopanga Wogulitsa

Pimaricin (yomwe imadziwikanso kuti natamycin, INN) ndi ya mankhwala opha tizilombo toyambitsa matenda omwe amapangidwa mwachilengedwe kudzera mu kuwiritsa kwa bakiteriya Streptomyces natalensis. Ndi mtundu wa macrolide polyene antifungal womwe umagwiritsidwa ntchito pochiza matenda a fungal keratitis, omwe ndi mtundu wa matenda a maso. Mu zamankhwala, ingagwiritsidwe ntchito pochiza matenda osiyanasiyana a fungal omwe amayamba chifukwa cha Candida, Aspergillus, Cephalosporium, Fusarium, ndi Penicillium. Mu mafakitale azakudya, ingagwiritsidwe ntchito ngati chosungira zachilengedwe kuti ipewe kukula kwa bowa. Njira yake yogwirira ntchito ndi yomangirira ku ergosterol mu nembanemba ya plasma ya bowa, kuletsa njira yolumikizirana kwa vacuoles ndi nembanemba yomwe imadalira ergosterol, kuletsa kukula kwa bowa. Imaletsanso kunyamula kwa amino acid ndi shuga kudzera mu kuletsa mapuloteni oyendera nembanemba.

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Pimaricin ndi macrocyclic tetraene yomwe idatulutsidwa koyamba kuchokera ku Streptomyces natalensis mu 1957. Pimaricin imagwira ntchito yolimbana ndi yisiti ndi bowa wopangidwa ndi ulusi pomangirira ku ergosterol kuti ilepheretse kukula kwa bowa. Mosiyana ndi polyenes zofanana, nystatin ndi filipin, pimaricin sisintha kulowa kwa nembanemba ya plasma. Pimaricin imagwiritsidwa ntchito m'makampani opanga chakudya pochiza tchizi pamwamba ngati choletsa nkhungu. Natamycin ndi mankhwala opha tizilombo a polyene omwe amapangidwa pang'ono. Natamycin sisungunuka bwino m'madzi ndipo sidzalowa mu epithelium yosasinthika ya cornea. Natamycin ndiye mankhwala okhawo opha tizilombo omwe amavomerezedwa kuti agwiritsidwe ntchito pa diso ndipo ndi mankhwala okhawo omwe amapezeka pamsika pochiza fungus keratitis. Natamycin, yomwe imadziwikanso kuti pimaracin, ndi ya banja la polyene la maantibayotiki; (gulu la mankhwala opha tizilombo omwe amalimbana ndi ma sterol a eukaryotic komanso makamaka ergosterol), ndipo ndi metabolite yachiwiri ya Streptomyces natalensis.

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Kulongedza Zinthu:

Zina Zowonjezera:

Kapangidwe kake	C33H47NO13
Kuyesa	99%
Maonekedwe	Ufa woyera mpaka wosayera
Nambala ya CAS	7681-93-8
Kulongedza	25KG
Moyo wa Shelufu	zaka 2
Malo Osungirako	Sungani pamalo ozizira komanso ouma
Chitsimikizo	ISO.