Neocuproine reagent ndi reagent yodziwira mkuwa, yoyera kapena yachikasu-bulauni, yokwiyitsa. Imagwiritsidwa ntchito makamaka ngati reagent yodziwira cuprous, photometric determining ya mkuwa, kudziwa shuga wambiri m'magazi; organic synthesis. Neocuproine hydrochloride monohydrate yagwiritsidwa ntchito poyesa kusungunuka kwa mkuwa mu Cu-Ni alloys pogwiritsa ntchito njira ya colorimetric. Yagwiritsidwanso ntchito pokonzekera yankho la complexing agent pophunzira mayeso a antioxidant capacity mu zitsanzo zamoyo kutengera Cu reducing complexes. Ingagwiritsidwe ntchito ngati precursor pokonzekera neocuproine, yogwiritsidwa ntchito ngati analytical reagent pozindikira mkuwa mu zitsanzo zachilengedwe pogwiritsa ntchito njira ya spectrophotometric.
Koma mankhwala oterewa ali ndi ntchito zosiyana kwambiri mu zamankhwala. Posachedwapa, Eribulin yavomerezedwa kuti igulitsidwe ndi National Medical Products Administration (NMPA) m'dziko langa kuti ichite malonda kwa odwala khansa ya m'mawere omwe amabwereranso kapena omwe amafalikira kwambiri omwe adalandira mankhwala a chemotherapy osachepera awiri (kuphatikizapo anthracyclines ndi taxans) m'mbuyomu. Yabweretsa njira yatsopano yochiritsira ku chemotherapy ya khansa ya m'mawere ku China, komanso imabweretsa njira zambiri zochiritsira odwala.
Eribulin ndi choletsa cha tubulin chosakhala cha taxane. Mosiyana ndi zoletsa za tubulin za taxane ndi vinblastine, Eribulin ili ndi njira yapadera yogwirira ntchito, zomwe zimapangitsa kuti Eribulin ikhale yothandiza kwa odwala omwe atatha kukana mankhwala; Eribulin ilinso ndi zotsatira zopanda poizoni, kuphatikizapo kukonzanso mitsempha yamagazi, kuwonjezera kutuluka kwa mankhwala ena m'malo otupa, kuphatikiza mankhwala ena, ndikubwezeretsa maselo a chotupa Kusintha kwa epidermal-mesenchymal ndi zina zotero.
Kuyambira pakupanga kwa halichondrin B konse, kugwiritsa ntchito zinthu zatsopano zamkuwa ngati zinthu zolumikizirana, mpaka kusintha kapangidwe ka Eribulin, mpaka kupanga kwa Eribulin m'mafakitale, asayansi ochokera kumakampani ophunzirira ndi opanga mankhwala akhala akufufuza kwa zaka zoposa 20. Zinthu zachilengedwe zochokera kunyanja zakhala mankhwala omwe amatha kuchiza khansa. Kafukufuku ndi chitukuko cha Eribulin ndichifukwa choti chinthu chatsopano cholumikizira mkuwa ndi chofunikira kwambiri ngati chinthu chachikulu cha API yake. Chinthu chatsopano cholumikizira mkuwa chili ndi gawo lalikulu ngati chinthu cholumikizirana ndi mankhwala komanso cholumikizirana poyeretsa zida zapamwamba.
Kapangidwe ka mamolekyu a Eribulin kali ndi malo 19 a chiral, ndipo njira zopangira ndi zazitali ngati masitepe 62. Mpaka pano, Eribulin imaonedwabe ndi makampani opanga mankhwala ngati mankhwala ovuta kwambiri omwe si a peptide omwe amapangidwa ndi kupanga mankhwala oyera, ndipo amatha kutchedwa Mount Everest mumakampani opanga mankhwala.
Kupambana kwa mndandanda wa Eribulin kukuwonetsa mtunda watsopano womwe makampani opanga mankhwala angakwanitse pakupanga mankhwala ndi kupanga mafakitale. Kumabweretsanso malingaliro ambiri okhudza matenda ndi chithandizo komanso njira zina kwa asing'anga aku China. Tikukhulupirira kuti m'tsogolomu, mankhwala atsopano a chemotherapeutic a Eribulin atha kubweretsa chiyembekezo chatsopano kwa odwala khansa ya m'mawere.
Nthawi yotumizira: Januwale-01-2021