Letrozole ndi gawo la m'badwo watsopano wa aromatase inhibitors omwe amasankha kwambiri ndipo ndi wopangidwa mwaluso wopangidwa ndi benzotriazole.Letrozole amaletsa aromatase kuti achepetse misinkhu ya estrogen, motero amalepheretsa estrogen kuti asalimbikitse kukula kwa chotupa.Ntchito yake mu vivo ndi mphamvu 150-250 kuposa ya m'badwo woyamba aromatase inhibitor Amarante.Chifukwa chosankha kwambiri, sichidzakhudza glucocorticoid, mineralocorticoid ndi ntchito za chithokomiro;ngakhale pa mlingo waukulu, sizikhala ndi zotsatira zolepheretsa kutulutsa kwa adrenal corticosteroid, kuwapatsa chiwerengero chachikulu cha mankhwala.