PhentolamineMesylate CAS:65-28-1

Phentolamine mesylate imagwira ntchito zosiyanasiyana zofunika kwambiri pa ntchito zachipatala ndi kafukufuku. Monga mankhwala amphamvu ochepetsa kuthamanga kwa magazi komanso ochepetsa kuthamanga kwa magazi, imagwiritsidwa ntchito pochiza matenda oopsa, makamaka pamavuto a pheochromocytoma, komwe kuchepetsa kuthamanga kwa magazi mwachangu ndikofunikira. Imapezekanso yothandiza pothana ndi matenda oopsa omwe amabwera chifukwa cha iatrogenic catecholamine panthawi ya opaleshoni ndi njira zina zamankhwala. Mu mano, phentolamine mesylate imagwiritsidwa ntchito ngati mankhwala oletsa ululu am'deralo, kuthandiza pakuwongolera mankhwala ofewa a minofu pambuyo pa njira za mano zomwe zimaphatikizapo mankhwala oletsa ululu am'deralo okhala ndi vasoconstrictor monga epinephrine. Zotsatira zake zochepetsa kuthamanga kwa magazi m'deralo zimathandiza kuchepetsa kutsekeka kwa magazi am'deralo ndikufulumizitsa kubwezeretsa kutuluka kwa magazi m'thupi. Kuphatikiza apo, mankhwalawa amagwiritsidwa ntchito pochiza matenda monga kupewa ndi kuchiza necrosis ya dermal yomwe imayamba chifukwa cha kuchotsedwa kwa mankhwala oletsa ululu, kuonetsetsa kuti minofu ikuyenda bwino. Kuphatikiza apo, imagwira nawo ntchito yofufuza ndi mayeso azachipatala omwe amafufuza momwe ingagwiritsidwire ntchito m'mikhalidwe yokhudzana ndi kulephera kwa mitsempha yamagazi, kulephera kugwira ntchito kwa erectile, komanso vuto la Raynaud, zomwe zimathandiza pakukula kwa matenda amtima ndi mkodzo. Udindo wa Phentolamine mesylate umafikira ku malo oyesera ngati chida mu kafukufuku wamankhwala ndi thupi, kuthandiza pakufufuza momwe adrenergic receptor imagwirira ntchito, mayankho a mitsempha yamagazi, komanso kusintha kwa ntchito ya mitsempha ya sympathetic. Kuthekera kwake kuletsa adrenergic receptors ndikukhudza kamvekedwe ka mitsempha yamagazi kumathandizira kumvetsetsa za kagwiridwe ka ntchito ka mtima ndi chitukuko cha njira zochiritsira zomwe zimayang'ana njira zolumikizirana ndi adrenergic. Ponseponse, ntchito zosiyanasiyana za phentolamine mesylate zikuwonetsa kufunika kwake mu zamankhwala azachipatala, mano, kafukufuku, ndi chitukuko cha mankhwala, kugogomezera kuthekera kwake kothandizira pakuwongolera bwino matenda amtima ndi kupititsa patsogolo chidziwitso cha sayansi chokhudzana ndi ntchito ya adrenergic receptor ndi kayendetsedwe ka mitsempha yamagazi.