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N,N-Bis(2-hydroxyethyl) -2-aminoethanesulfonic acid sodium mchere CAS:66992-27-6
N,N-Bis(2-hydroxyethyl) -2-aminoethanesulfonic acid mchere wa sodium, womwe umadziwikanso kuti HEPES sodium salt, ndi mankhwala omwe amagwiritsidwa ntchito ngati pH buffering agent mu biological and chemical laboratories.Imathandizira kukhala ndi pH yokhazikika, ndikupangitsa kuti ikhale yoyenera kugwiritsa ntchito monga chikhalidwe cha ma cell, kuyesa kwa ma enzyme, maphunziro a protein, electrophoresis, ndi kupanga mankhwala.Mchere wa HEPES wa sodium umatsimikizira mikhalidwe yabwino kwambiri yazachilengedwe ndikuwonjezera kulondola komanso kudalirika kwa zotsatira zoyeserera.
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2'-(4-METHYLUMBELLIFERYL)-ALPHA-DN-ACETYLNEURAMINIC ACID SODIUM SALT CAS:76204-02-9
2'- (4-Methylumbliferyl) -alpha-DN-acetylneuraminic acid mchere wa sodium ndi mankhwala omwe amagwiritsidwa ntchito kwambiri pofufuza ndi kufufuza.Ndiwochokera ku sialic acid, mtundu wa molekyulu yamafuta yomwe imapezeka pamwamba pa maselo.
Pawiriyi imagwiritsidwa ntchito ngati gawo lapansi la michere yotchedwa neuraminidases, yomwe imachotsa zotsalira za sialic kuchokera ku glycoproteins ndi glycolipids.Ma enzymes awa akamagwira ntchito pa mchere wa sodium wa 2'- (4-Methylumbelliferyl) -alpha-DN-acetylneuraminic acid, umatulutsa mankhwala a fulorosenti omwe amadziwika kuti 4-methylumbelliferon.
Fluorescence yopangidwa ndi pawiri imatha kuyeza ndikuwerengedwa, ndikudziwitsanso ntchito ya ma enzymes a neuraminidase.Izi ndizothandiza makamaka pophunzira matenda osiyanasiyana ndi mikhalidwe yokhudzana ndi kagayidwe kachakudya ka sialic acid.
Mankhwalawa amagwiritsidwanso ntchito pozindikira matenda, monga kuzindikira matenda obwera chifukwa cha ma virus omwe amakhudza ntchito ya neuraminidase.M'mayeserowa, mankhwalawa amagwiritsidwa ntchito kuti azindikire kukhalapo kwa tizilombo toyambitsa matenda kapena kuyesa mphamvu ya neuraminidase inhibitors mu mankhwala oletsa tizilombo toyambitsa matenda.
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TAPSO CAS: 68399-81-5 Mtengo Wopanga
TAPSO (3--[N-tris(hydroxymethyl)methyl]amino] -2-hydroxypropanesulfonic acid) ndi zwitterionic buffer yomwe imagwiritsidwa ntchito pofufuza zamoyo ndi zamankhwala.Ndilothandizira bwino lomwe lili ndi pKa pafupi ndi pH ya thupi, kupangitsa kuti ikhale yoyenera kusunga pH yokhazikika pakuyesa kwachilengedwe.TAPSO nthawi zambiri imagwiritsidwa ntchito poyeretsa mapuloteni, kuyesa kwa ma enzyme, chikhalidwe cha cell, ndi kugwiritsa ntchito electrophoresis.Kusungunuka kwake m'madzi komanso kusokoneza pang'ono kwachilengedwe kumapangitsa kukhala chisankho chodziwika bwino pakati pa asayansi.TAPSO imadziwika chifukwa cha kuchepa kwake pakuchita kwa ma enzyme ndipo imagwiritsidwa ntchito ngati m'malo mwa ma buffering ena monga Tris kapena phosphate buffers.
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N-Acetyl-L-cysteine CAS: 616-91-1
N-Acetyl-L-cysteine (NAC) ndi mawonekedwe osinthidwa a amino acid cysteine.Amapereka gwero la cysteine ndipo amatha kusinthidwa mosavuta kukhala tripeptide glutathione, antioxidant wamphamvu m'thupi.NAC imadziwika chifukwa cha antioxidant ndi mucolytic properties, zomwe zimapangitsa kuti zikhale zothandiza pazinthu zosiyanasiyana zaumoyo.
Monga antioxidant, NAC imateteza maselo kuti asawonongeke chifukwa cha ma radicals aulere, mitundu ya okosijeni yokhazikika, ndi poizoni.Imathandiziranso kaphatikizidwe ka glutathione, komwe kumagwira ntchito yofunika kwambiri pakuchotsa poizoni m'thupi ndikusunga chitetezo chokwanira.
NAC yaphunziridwa chifukwa cha zopindulitsa zake paumoyo wa kupuma, makamaka kwa anthu omwe ali ndi matenda monga bronchitis, COPD, ndi cystic fibrosis.Nthawi zambiri amagwiritsidwa ntchito ngati expectorant kuti athandizire kuonda komanso kumasula ntchofu, zomwe zimapangitsa kuti zikhale zosavuta kuchotsa mpweya.
Kuphatikiza apo, NAC yawonetsa lonjezo lothandizira thanzi lachiwindi pothandizira kuchotsa zinthu zapoizoni, monga acetaminophen, chothandizira kupweteka wamba.Zitha kukhalanso ndi zoteteza ku chiwindi kuwonongeka chifukwa chakumwa mowa.
Kuphatikiza pa mphamvu zake zoteteza antioxidant ndi kupuma, NAC yafufuzidwa chifukwa cha zopindulitsa zake m'maganizo.Kafukufuku wina akuwonetsa kuti zitha kukhala ndi zotsatira zabwino pazovuta zamalingaliro, monga kupsinjika maganizo ndi matenda okakamiza (OCD).
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PIPES CAS: 5625-37-6 Mtengo Wopanga
PIPES (piperazine-1,4-bisethanesulfonic acid) ndi zwitterionic buffering compound yomwe imagwiritsidwa ntchito pofufuza zamoyo ndi biochemical.Ndi pH buffer yogwira ntchito yokhala ndi mphamvu yayikulu yosunga pH yokhazikika mumtundu wa pH wa 6.1 mpaka 7.5.PIPES ili ndi zosokoneza pang'ono ndi ma biomolecules ndipo ndiyoyenera kuyesa kutengera kutentha.Nthawi zambiri amagwiritsidwa ntchito mu njira za gel electrophoresis ndi kupanga mankhwala monga wothandizira wokhazikika.Ponseponse, PIPES ndi gulu losunthika komanso logwiritsidwa ntchito kwambiri pamayesero osiyanasiyana.
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2',6'-DiMethylcarbonylphenyl-10-sulfopropylacridiniumM-9-carboxylate 4'-NHS Ester CAS:194357-64-7
2',6'-DiMethylcarbonylphenyl-10-sulfopropylacridinium-9-carboxylate 4'-NHS ester ndi mankhwala omwe ali ndi mamolekyu ovuta.Lili ndi gulu la sulfopropylacridinium ndi gulu logwira ntchito la carboxylate ester.Kukhalapo kwa ester moiety kumasonyeza kuti ndi yotakasuka ndipo ingagwiritsidwe ntchito ngati chizindikiro kapena kusintha kwa ma biomolecules.
Gulu la sulfpropylacridinium la gululi likuwonetsa kuti litha kugwiritsidwa ntchito poyesa ma fluorescence, pomwe lingagwiritsidwe ntchito ngati kafukufuku wa fulorosenti kapena utoto kuti azindikire ndikuwunika ma biomolecules.Zitha kukhalanso zofunikira pakufufuza kwama cell, monga ma intracellular calcium signing.
Kuphatikizidwa kwa gulu la ester la NHS limasonyeza kuti likhoza kuchitapo kanthu ndi ma amine oyambirira, monga omwe amapezeka mu mapuloteni kapena ma peptide, kuti apange ma amide okhazikika.Kuchitanso kumeneku kumapangitsa kukhala kothandiza pakugwiritsa ntchito kwa bioconjugation, komwe kumatha kugwiritsidwa ntchito kulemba kapena kusintha ma biomolecules ndi mamolekyu ena ogwira ntchito, monga fluorophores kapena ma tag.
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5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-glucosaminide CAS:4264-82-8
5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-glucosaminide ndi gulu lomwe limagwiritsidwa ntchito m'maphunziro osiyanasiyana a biochemical, makamaka pozindikira ndikuwona zochitika za enzyme.Ndi gawo lapansi lomwe limatha kupangidwa ndi hydrolyzed ndi michere inayake, zomwe zimapangitsa kutulutsa kwamtundu wamtundu kapena fulorosenti.
Pagululi nthawi zambiri amagwiritsidwa ntchito poyesa kudziwa kukhalapo ndi zochita za michere monga beta-galactosidase ndi beta-glucuronidase.Ma enzymes awa amadula magulu a acetyl ndi glucosaminide kuchokera ku gawo lapansi, zomwe zimapangitsa kupanga chromophore ya buluu kapena yobiriwira.
Mapangidwe apadera a 5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-glucosaminide amalola kuti azindikire mosavuta ndi kuchuluka kwa ntchito ya enzyme.Kugwiritsiridwa ntchito kwake mu njira zosiyanasiyana zoyesera, kuphatikizapo histochemistry, immunohistochemistry, ndi ma cell-based assays, zathandizira kumvetsetsa bwino ntchito za enzyme.
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Mchere wamchere wa Sodium CAS: 139-41-3 Mtengo Wopanga
N,N-Bis(2-hydroxyethyl) glycine sodium mchere ndi mankhwala ntchito ngati buffering agent mu zosiyanasiyana biochemical ndi biophysical ntchito.Zimathandizira kukhala ndi pH yokhazikika pamayesero, ndikupangitsa kuti ikhale yothandiza mu maphunziro a enzyme, kafukufuku wamapuloteni, chikhalidwe cha ma cell, ndi njira zotsekera zaku Western.
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Spinosad CAS: 131929-60-7 Wopanga Wopanga
Spinosad ndi gulu la 5 nicotinic acetylcholine receptor agonist, lomwe limayambitsa kusakhazikika kwa minofu ndi kunjenjemera kwachiwiri kwa motor neuron activation.Kuwonekera kwa nthawi yayitali kumayambitsa ziwalo ndi kufa kwa utitiri.Imfa ya utitiri imayamba pakangotha mphindi 30 mutamwa mankhwalawa ndipo pakatha maola 4 mumatha.Spinosad sichimalumikizana ndi malo omangira a mankhwala ena ophera tizilombo (GABA-ergic kapena nicotinic).
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Rotenone CAS: 83-79-4 Wopanga Wopanga
Rotenone ndi m'mimba komanso poizoni wokhudzana ndi arthropods.Kugwetsa kwake mwachangu kumachitika chifukwa chakuchepetsa kupezeka kwa nicotinamide adenine dinucleotide kuti igwire ntchito ngati cofactor munjira zosiyanasiyana zama biochemical kuphatikiza kuzungulira kwa Krebs, potero kuletsa ma enzymes opumira a mitochondrial.
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Diazinon CAS: 333-41-5 Wopanga Wopanga
Diazinon imapezeka mu mawonekedwe amadzimadzi opanda mtundu kapena akuda.Amasungunuka pang'ono m'madzi koma amasungunuka mu petroleum ether, mowa, ndi benzene.Diazinon imagwiritsidwa ntchito polimbana ndi mitundu yosiyanasiyana yaulimi ndi tizirombo ta m'nyumba.Izi zikuphatikizapo tizirombo m'nthaka, zomera zokongola, zipatso, masamba, mbewu ndi tizirombo ta m'nyumba monga ntchentche, utitiri, ndi mphemvu.
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Avermectin CAS: 71751-41-2 Wopanga Wopanga
Abamectin (Avermectin) ndi mankhwala oopsa a mitsempha.Njira yake ikuyang'ana ku GABAA receptor ya insect neuron synapse kapena neuromuscular synapse, kusokoneza kusamutsa kwa chidziwitso cha mathero a mitsempha, kulimbikitsa mathero a mitsempha kuti amasule neurotransmitter inhibitor γ-aminobutyric acid (GA-BA), kuchititsa kutsegula kwakukulu kwa mitsempha. Njira ya GABA-gated chloride yokhala ndi chloride-activating effect.
