Chowonjezera cha Mapuloteni Kinase KT5823 CAS:126643-37-6 Chithunzi Chodziwika

Mapuloteni Kinase Supplement KT5823 CAS:126643-37-6

Chowonjezera cha protein kinase KT5823 ndi choletsa chaching'ono cha molekyulu chomwe chimalimbana ndikuletsa ntchito ya protein kinase. Ma protein kinase ndi ma enzyme omwe amafosforasitsa mapuloteni powonjezera magulu a phosphate ku ma amino acid residues enaake, makamaka serine, threonine, kapena tyrosine. Njira yofosforasitsa imeneyi imagwira ntchito yofunika kwambiri m'njira zosiyanasiyana zolumikizirana ndi maselo, kuwongolera magwiridwe antchito a mapuloteni, komanso kuwongolera njira zamaselo monga kukula kwa maselo, kugawikana, kusiyanitsa, ndi apoptosis.

KT5823 imagwiritsidwa ntchito kwambiri mu kafukufuku kuti ifufuze momwe mapuloteni a protein kinases amagwirira ntchito komanso njira zolumikizirana. Mwa kuletsa mapuloteni a protein kinases, KT5823 ingathandize ofufuza kudziwa mapuloteni ndi njira zomwe zimakhudzidwa ndi ntchito ya kinase. Chidziwitsochi chingathandize kumvetsetsa ntchito ya mapuloteni a protein kinases m'maselo ndi kuzindikira zolinga zatsopano zochiritsira.

Oda kapena Pemphani Mtengo

Tsatanetsatane wa Zamalonda

Ma tag a Zamalonda

Kugwiritsa Ntchito ndi Zotsatira zake

Chowonjezera cha protein kinase KT5823 ndi choletsa protein kinase G (PKG) chomwe chimagwiritsidwa ntchito kwambiri, makamaka cholimbana ndi mtundu wa I isoform PKG-1. PKG ndi serine/threonine kinase yomwe imagwira ntchito yofunika kwambiri pazochitika zosiyanasiyana zamaselo monga kupumula minofu yosalala, kusonkhana kwa ma platelet, ndikuwongolera kufalikira kwa magazi m'mitsempha.

Chotsatira chachikulu cha KT5823 ndikuletsa ntchito ya PKG-1 mwa kupikisana ndi ATP kumangirira ku kinase domain. Mwa kuletsa PKG-1, KT5823 ikhoza kusokoneza njira zolumikizirana zomwe zili pansi pa PKG-1 activation, kuphatikizapo cGMP-dependent signaling cascades.

Kugwiritsa ntchito KT5823 makamaka kumachitika mu kafukufuku kuti afufuze momwe PKG-1 imagwirira ntchito komanso momwe imalumikizirana ndi zizindikiro. Kugwiritsa ntchito kwake poletsa ntchito ya PKG-1 kumathandiza ofufuza kufufuza ntchito za PKG-1 m'njira zosiyanasiyana za thupi ndi matenda. Ntchito zina zapadera za KT5823 ndi izi:

Kufufuza za kupumula kwa minofu yosalala: PKG-1 imagwira ntchito yofunika kwambiri pakupumula kwa minofu yosalala. Mwa kuletsa PKG-1 pogwiritsa ntchito KT5823, ofufuza amatha kuphunzira njira ndi njira zomwe zimakhudzidwa pakupumula kwa minofu yosalala, zomwe ndizofunikira m'magawo monga kafukufuku wa mtima.

Kuphunzira za kusonkhana kwa ma platelet: PKG-1 imayang'aniranso kusonkhana kwa ma platelet ndi kupangika kwa magazi kuundana. Kuletsa PKG-1 ndi KT5823 kumathandiza ofufuza kuwunika momwe ntchito ya PKG-1 imakhudzira ntchito ya ma platelet ndikumvetsetsa njira zomwe zimakhudzidwa.

Kufufuza zolinga za PKG-1 zomwe zili pansi pa madzi: Mwa kuletsa PKG-1, ofufuza amatha kuzindikira ndikuphunzira zolinga za pansi pa madzi ndi zomwe zimapangitsa kuti PKG-1 iwonetsedwe, zomwe zimatithandiza kudziwa momwe maselo amagwirira ntchito pogwiritsa ntchito PKG-1.

Kulongedza Zinthu:

Zina Zowonjezera:

Kapangidwe kake	C29H25N3O5
Kuyesa	99%
Maonekedwe	Ufa woyera
Nambala ya CAS	126643-37-6
Kulongedza	Kakang'ono komanso kochuluka
Moyo wa Shelufu	zaka 2
Malo Osungirako	Sungani pamalo ozizira komanso ouma
Chitsimikizo	ISO.