(R)-tert-butyl 4,5,6,7-tetrahydro-1H-indazol-5-ylcarbamate CAS:955406-14-1

(R)-tert-butyl 4,5,6,7-tetrahydro-1H-indazol-5-ylcarbamate imagwira ntchito yofunika kwambiri ngati pakati pa kupanga mankhwala ovuta, opatsa thanzi omwe ali ndi ntchito zomwe zingatheke pa mankhwala. Chikhalidwe chake cha chiral ndi mawonekedwe ake apadera zimayiyika ngati gawo lofunikira kwambiri popanga mankhwala a enantiopure, omwe ndi ofunikira pakupanga mankhwala. Mwa kuphatikiza chomangira ichi m'maselo, ofufuza amatha kufufuza mankhwala atsopano omwe akuyang'ana madera ochiritsira monga matenda a mitsempha yapakati, matenda opatsirana, kapena khansa. Mu chemistry yamankhwala, chomangirachi chingakhale poyambira popanga mankhwala omwe angakhale nawo, pogwiritsa ntchito stereochemistry yake kuti asinthe zochita zamoyo ndi katundu wa pharmacokinetic. Gulu la tert-butyl limapereka choletsa cha steric ndipo limakhudza kuyanjana kwa chomangiracho ndi zolinga zamoyo, zomwe zimathandiza pakufufuza mankhwala atsopano. Kuphatikiza apo, m'malo ophunzirira ndi mafakitale, ofufuza angagwiritse ntchito chomangirachi kukonzekera malaibulale amitundu yosiyanasiyana yochokera ku maphunziro a ubale wa kapangidwe ndi ntchito, zomwe zimathandiza kuzindikira mankhwala a lead omwe ali ndi zotsatira zomwe akufuna pazamoyo. Udindo wake pakupanga mankhwala umafikira pakupanga mankhwala ophatikizana ndi mankhwala komanso kupanga njira zatsopano zopangira, zomwe zimasonyeza kufunika kwake kwakukulu m'magawo asayansi. Ponseponse, (R)-tert-butyl 4,5,6,7-tetrahydro-1H-indazol-5-ylcarbamate imagwira ntchito yofunika kwambiri pakufunafuna njira zatsopano zopezera mankhwala komanso kupanga mankhwala osafanana, zomwe zimapangitsa kuti pakhale njira yopangira mamolekyu osiyanasiyana ogwira ntchito m'thupi komanso mankhwala ophatikizana.