Simvastatin CAS:79902-63-9 Wopanga Wogulitsa

Simvastatin ndi yopangidwa pang'ono, yosagwirizana ndi madzi pang'ono, yofanana ndi lovastatin. Monga lovastatin, simvastatin ndi choletsa cha HMG-CoA reductase ndipo imagwiritsidwa ntchito pochiza kuti ichepetse cholesterol ya LDL. Posachedwapa, ma statin akhala ma probe ofunikira kwambiri a biochemical mu biology ya maselo. Kutenga nawo mbali pazochitika zambiri kungagwirizane ndi momwe amagwirira ntchito, komabe, momwe zochita za zotsatira zina zambiri zimagwirira ntchito sizikuonekera bwino. Simvastatin ndi choletsa chapadera cha HMG-CoA reductase, enzyme yomwe imayambitsa kusintha kwa HMG-CoA kukhala mevalonate, sitepe yoyamba mu biosynthesis ya cholesterol. Imagwiritsidwa ntchito pochiza hypercholesterolemia, chifukwa imachepetsa kuchuluka kwa lipoproteins otsika kwambiri ndi triglycerides, ndikukweza kuchuluka kwa lipoproteins okwera kwambiri.