Sodium Alpha-Ketoisocaproate CAS:4502-00-5 Wopanga Wopanga

Sodium Alpha-Ketoisocaproate ndi metabolite ya leucine yomwe imadziwika kuti imathandizira kutulutsa kwa insulin kuchokera ku ma βcell a kapamba.Kulowetsedwa kwamkati kwa aα-Ketoisocaproate kumapezeka kuti kumathandizira, endotoxemic condition.Zotsatira zake, matupi a ketone omwe amapezeka pakutembenuka kwake, amatha kukhala ngati gwero lamphamvu.Kuchuluka kwa α-Ketoisocaproic acid kumadziwika ndi ketoaciduria ya nthambi, zomwe zimachitika chifukwa cha kusowa kwa unyolo wa L-2-keto acid dehydrogenase.α-Ketoisocaproic acid imayambitsa kupatukana mu oxidative phosphorylation reaction ndipo imakhala ngati metabolic inhibitor ya α-ketoglutarate dehydrogenase.Chifukwa chake, kumabweretsa chilema mu mitochondrial homeostasis, yomwe imawonedwa mu nthambi za ketoaciduria.