Sodium Alpha-Ketoisocaproate CAS:4502-00-5 Wopanga Wogulitsa

Sodium Alpha-Ketoisocaproate ndi metabolite ya leucine yomwe imadziwika kuti imayambitsa kutulutsa insulin kuchokera ku ma β cell a kapamba. Kulowetsedwa kwa aα-Ketoisocaproate m'mimba kumapezeka kuti kumathandizira, kumachepetsa vuto la endotoxemia. Ma ketone bodies omwe amapezeka chifukwa cha kusintha kwake, amatha kukhala gwero lamphamvu. Kusonkhanitsa kwa α-Ketoisocaproic acid kumadziwika mu ketoaciduria ya nthambi, yomwe imayamba chifukwa cha kusowa kwa ntchito ya L-2-keto acid dehydrogenase ya nthambi. α-Ketoisocaproic acid imayambitsa kusokonezeka kwa oxidative phosphorylation reaction ndipo imagwira ntchito ngati choletsa kagayidwe kachakudya ka α-ketoglutarate dehydrogenase. Chifukwa chake, kumabweretsa vuto mu mitochondrial homeostasis, lomwe limapezeka mu ketoaciduria ya nthambi.