tert-Butyl (3S,4R)-3-amino-4-phenylpyrrolidine-1-carboxylate CAS:1643979-48-9

Tert-butyl (3S,4R)-3-amino-4-phenylpyrrolidine-1-carboxylate imagwira ntchito yofunika kwambiri ngati cholumikizira chosinthika pakupanga mankhwala ovuta, opatsa thanzi omwe ali ndi ntchito zomwe zingatheke pa mankhwala. Kuphatikizidwa kwake mu ma framework a molekyulu kumalola ofufuza kufufuza mankhwala atsopano omwe akuyang'ana madera ochiritsira monga matenda a mitsempha yapakati, kusamalira ululu, kapena matenda amisala. Kupezeka kwa chiral pyrrolidine core ndi ntchito ya tert-butyl kumayambitsa reactivity yeniyeni ndi katundu wa pharmacophoric, zomwe zimapangitsa kuti ikhale yofunikira pa kafukufuku wa chemistry yamankhwala. Mu zoyesayesa zopeza mankhwala, mankhwalawa atha kukhala poyambira popanga mankhwala omwe angakhale nawo, pogwiritsa ntchito mawonekedwe ake kuti asinthe ntchito ya zamoyo ndi katundu wa pharmacokinetic. Kuphatikiza apo, chikhalidwe cha chiral cha molekyulu chingakhudze kuyanjana kwake ndi zolinga zamoyo, zomwe zingakhudze katundu wake wa mankhwala ndikuwonjezera ntchito yake pakupanga mankhwala. Kuphatikiza apo, m'malo ophunzirira ndi mafakitale, ofufuza angagwiritse ntchito izi pokonzekera malaibulale amitundu yosiyanasiyana yochokera ku maphunziro a ubale wa kapangidwe ndi ntchito, kuthandizira kuzindikira mankhwala a lead omwe ali ndi zotsatira zomwe akufuna pazamoyo. Udindo wake pakupanga mankhwala umafikira pakupanga mankhwala ophatikizana ndi mankhwala komanso kupanga njira zatsopano zopangira, kuwonetsa kufunika kwake kwakukulu m'magawo asayansi. Ponseponse, tert-butyl (3S,4R)-3-amino-4-phenylpyrrolidine-1-carboxylate imagwira ntchito yofunika kwambiri pakufunafuna njira zatsopano zopezera mankhwala ndi kafukufuku wa mankhwala, kupereka nsanja yopangira mamolekyu osiyanasiyana ogwira ntchito m'thupi komanso mankhwala ophatikizana.