Tofacitinib CAS:477600-75-2 Wopanga Wopanga

Tofacitinib ndi mankhwala ochizira nyamakazi ya nyamakazi (RA), psoriasis, kutupa kwamatumbo, ndi matenda ena ammunological, komanso kupewa kukana kuyika ziwalo.Ndi inhibitor ya enzyme Janus kinase 3 (JAK3), zomwe zikutanthauza kuti zimasokoneza njira yowonetsera ya JAK-STAT yomwe imatumiza uthenga kunja kwa selo kupita ku cell cell, zomwe zimakhudza kulembedwa kwa DNA.Posachedwapa zasonyezedwa mu chitsanzo cha murine cha nyamakazi yokhazikika, tofacitinib imakula mofulumira matenda mwa kulepheretsa kupanga oyimira pakati otupa ndi kupondereza majeremusi odalira STAT1 mu minofu yolumikizana. njira, kutanthauza kuti tofacitinib ikhoza kupereka chithandizo chamankhwala kudzera m'njira zomwe sizimangoletsa kuletsa kwa JAK3.