Tofacitinib CAS:477600-75-2 Wogulitsa Wopanga

Tofacitinib ndi mankhwala ochizira matenda a nyamakazi (RA), psoriasis, matenda otupa m'matumbo, ndi matenda ena a chitetezo chamthupi, komanso kupewa kukana kuikidwa kwa ziwalo. Ndi choletsa cha enzyme Janus kinase 3 (JAK3), zomwe zikutanthauza kuti chimasokoneza njira yolumikizirana ya JAK-STAT yomwe imatumiza uthenga kunja kwa selo kupita ku selo, zomwe zimakhudza kulembedwa kwa DNA. Posachedwapa yawonetsedwa mu chitsanzo cha murine cha nyamakazi yodziwika bwino, tofacitinib imawongolera matenda mwachangu poletsa kupanga kwa zoyambitsa kutupa ndikuletsa majini odalira STAT1 m'minofu yolumikizana. Kugwira ntchito kumeneku mu chitsanzo cha matendawa kunagwirizana ndi kuletsa njira zonse ziwiri za JAK1 ndi 3 zolumikizirana, zomwe zikusonyeza kuti tofacitinib ikhoza kukhala ndi phindu pochiza kudzera m'njira zomwe sizimangokhala zoletsa JAK3.