Uridine-5′-diphosphoglucuronic acid trisodium mchere CAS:63700-19-6

Kuchotsa poizoni m'thupi: UDP-glucuronic acid ndi molekyu yofunika kwambiri yomwe imakhudzidwa ndi kusintha kwa thupi kwa ma xenobiotics ndi mankhwala achilengedwe. Imagwira ntchito ngati choyambira cha kupanga ma glucuronides, omwe ndi ma conjugates osungunuka m'madzi omwe amatha kuchotsedwa mosavuta m'thupi. Njira yochotsera poizoni m'thupi iyi imathandiza kuthetsa ndikuchotsa zinthu zomwe zingakhale zoopsa, monga mankhwala osokoneza bongo, poizoni m'chilengedwe, ndi zinthu zina zomwe zimayambitsa kagayidwe kachakudya m'thupi.

Kagayidwe ka mankhwala: Mankhwala ambiri amadutsa mu glucuronidation, njira yomwe UDP-glucuronic acid imalumikizana ndi molekyulu ya mankhwala, zomwe zimapangitsa kuti metabolite ya glucuronide ipangidwe. Kachitidwe ka glucuronidation kameneka nthawi zambiri kamathandizira kuchotsa mankhwala m'thupi ndikuthandizira kutulutsa kwawo kudzera mu mkodzo kapena ndulu. Mchere wa UDP-glucuronic acid trisodium umagwiritsidwa ntchito nthawi zambiri mu kafukufuku wofufuza kagayidwe ka mankhwala ndi mankhwala.

Chida Chofufuzira: UDP-glucuronic acid Mchere wa trisodium umagwiritsidwa ntchito kwambiri ngati chida chofufuzira m'maphunziro osiyanasiyana okhudzana ndi kagayidwe ka mankhwala, enzymology, ndi toxicology. Umapereka gwero la UDP-glucuronic acid pakuyesera mu vitro ndipo umathandiza ofufuza kufufuza momwe glucuronidation imakhudzira kuchotsedwa kwa mankhwala, kupezeka kwa bioavailability, komanso momwe mankhwala amagwirizanirana ndi mankhwala.

Glycosylation: UDP-glucuronic acid imagwiranso ntchito mu glycosylation reactions, komwe imagwira ntchito ngati wopereka zigawo za glucuronic acid popanga glycosaminoglycans (GAGs) ndi proteoglycans. Mamolekyu awa ali ndi ntchito zofunika kwambiri pazochitika zosiyanasiyana zamoyo, kuphatikizapo kumamatira kwa maselo, kupanga matrix akunja kwa maselo, ndi kuzindikiritsa.