β-Nicotinamide Mononucleotide CAS:1094-61-7

β-Nicotinamide mononucleotide (NMN) imagwiritsidwa ntchito pophunzira ma motif omangira mkati mwa ma aptamers a RNA ndi njira zoyatsira ribozyme zomwe zimaphatikizapo zidutswa za RNA zomwe zimayambitsidwa ndi β-nicotinamide mononucleotide (β-NMN). NMN ndi nucleotide yochokera ku ribose ndi nicotinamide. Niacinamide (nicotinamide,) ndi yochokera ku vitamini B3, yomwe imadziwikanso kuti niacin.) Monga choyambitsa matenda a biochemical a NAD+, ingakhale yothandiza popewa pellagra.
β-Nicotinamide mononucleotide ndi gawo lapakati pa biosynthesis ya nicotinamide adenine dinucleotide (NAD+). Nicotinamide phosphoribosyltransferase (Nampt) imayambitsa condensation ya nicotinamide ndi 5-phosphoribosyl-1-pyrophosphate kuti ipange β-NMN, yomwe pambuyo pake imasinthidwa kukhala NAD+ ndi β-NMN adenyltransferase. Pa 50-100 μM, β-NMN yagwiritsidwa ntchito kupititsa patsogolo biosynthesis ya NAD ndi glucose-stimulated insulin secretion mu chitsanzo cha mbewa cha Nampt+/- matenda a kagayidwe kachakudya, zomwe zikuwonetsa gawo la Nampt mu ntchito ya maselo a β.