1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile CAS:2158267-70-8

1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile imagwira ntchito yofunika kwambiri ngati pakati pa kupanga mankhwala ovuta, opatsa thanzi omwe ali ndi ntchito zomwe zingatheke pa mankhwala. Kuphatikizidwa kwake mu ma framework a molecular kumathandiza ofufuza kufufuza mankhwala atsopano omwe akuyang'ana madera osiyanasiyana ochiritsira monga kinase inhibitors, fluorescent probes, kapena kugwiritsa ntchito mankhwala. Kupezeka kwa pyrazole core ndi gulu la dioxaborolane kumayambitsa reactivity yeniyeni ndi katundu wa pharmacophoric, zomwe zimapangitsa kuti ikhale yofunikira pa kafukufuku wa mankhwala. Mu zoyesayesa zopeza mankhwala, mankhwalawa angagwiritsidwe ntchito ngati poyambira popanga mankhwala omwe angakhalepo, pogwiritsa ntchito mawonekedwe ake kuti asinthe ntchito ya zamoyo ndi katundu wa pharmacokinetic. Kuphatikiza apo, gulu logwira ntchito la dioxaborolane limapereka mwayi wowonjezera kutulutsa ndi kuphatikiza mankhwala, zomwe zingayambitse kukulitsa mamolekyu atsopano okhala ndi katundu wowonjezera wa zamoyo komanso mbiri yabwino ya pharmacokinetic. Kuphatikiza apo, m'malo ophunzirira ndi mafakitale, ofufuza angagwiritse ntchito njira yomangira iyi kukonzekera malaibulale a zinthu zosiyanasiyana zotumphukira kuti aphunzire za ubale wa kapangidwe kake ndi ntchito, zomwe zimathandiza kuzindikira mankhwala a lead omwe ali ndi zotsatira zabwino zamoyo. Udindo wake pakupanga mankhwala umafikira pakupanga mankhwala ophatikizana ndi kupanga njira zatsopano zopangira, kuwonetsa kufunika kwake kwakukulu m'magawo asayansi. Ponseponse, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile imagwira ntchito yofunika kwambiri pakufunafuna kupeza mankhwala atsopano ndi kafukufuku wa mankhwala, kupereka nsanja yopangira mamolekyu osiyanasiyana ogwira ntchito m'thupi komanso mankhwala ophatikizana.