Candesartana Cilexetila CAS:145040-37-5

Candesartan cilexetil ndi mankhwala ochokera ku candesartan, yomwe ndi mankhwala amphamvu, ogwira ntchito nthawi yayitali, komanso osankha angiotensin II receptor AT1 antagonist, yomwe imapangidwa ndi candesartan. Imasungunuka mwachangu kukhala candesartan panthawi yoyamwa m'mimba. Pambuyo pa hydrolysis ya candesartan cilexetil kupita ku candesartan panthawi yoyamwa m'mimba, candesartan imapikisana ndi angiotensin II kuti imange angiotensin II receptor subtype 1 AT1 mu minofu yosalala ya mitsempha yamagazi, kuletsa angiotensin II-mediated vasoconstriction ndikuyambitsa vasodilatation. Kuphatikiza apo, kutsutsa kwa AT1 mu adrenal gland kumaletsa kupanga ndi kutulutsa kwa aldosterone komwe kumayambitsidwa ndi angiotensin II ndi adrenal cortex; kutulutsa kwa sodium ndi madzi kumawonjezeka, kutsatiridwa ndi kuchepa kwa kuchuluka kwa magazi m'magazi ndi kuthamanga kwa magazi.