Candesartan CAS:139481-59-7 Wopanga Wogulitsa Chithunzi Chodziwika

Candesartan CAS:139481-59-7 Wogulitsa Wopanga

Candesartan ndi antagonist wa angiotensin II receptor I (AT1), IC50s=1.12 ndi 2.86 nM ya ng'ombe adrenal cortex ndi rabbit aorta motsatana. Amaletsa kufupika kwa angiotensin II komwe kumachitika chifukwa cha mikwingwirima ya aortic ya kalulu popanda kukhudza kufupika komwe kumachitika chifukwa cha zinthu zina monga norepinephrine, KCl, serotonin, PGF2α kapena endothelin.

Oda kapena Pemphani Mtengo

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Candesartan ndi mankhwala osankha a AT1 (angiotensin II receptor 1). Kutsutsana kwa ma angiotensin receptors kumaletsa vasoconstriction ndi kupanga aldosterone, zomwe zimapangitsa kuti kuchuluka kwa madzi ndi sodium m'magazi kuchepe. Amawonetsa mphamvu zochepetsa kuthamanga kwa magazi m'zinyama. Amagwiritsidwa ntchito pochiza kulephera kwa mtima, ngati antihypertensive. Candesartan siyimakhudza moyo wa maselo kapena kuchulukana koma imawonjezera kufalikira kwa VEGF ndi interleukin-8 m'malo olimidwa a maselo a KU-19-19. Candesartan (0.1 nM) ikhoza kuchepetsa kuyankha kwakukulu kwa angiostensin II ndi pafupifupi 50%.

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Kulongedza Zinthu:

Zina Zowonjezera:

Kapangidwe kake	C24H20N6O3
Kuyesa	99%
Maonekedwe	Ufa woyera
Nambala ya CAS	139481-59-7
Kulongedza	1KG 25KG
Moyo wa Shelufu	zaka 2
Malo Osungirako	Sungani pamalo ozizira komanso ouma
Chitsimikizo	ISO.