-
Adenosine CAS:58-61-7
Adenosine ndi nucleoside yopangidwa ndi adenine ndi ribose, yomwe imagwira ntchito yofunika kwambiri mu kagayidwe ka maselo. Imagwira ntchito ngati maziko omangira adenosine triphosphate (ATP), ndalama yayikulu yamphamvu m'machitidwe a zamoyo. Kupatula ntchito zake zokhudzana ndi mphamvu, adenosine imagwira ntchito m'njira zosiyanasiyana za thupi, kuphatikizapo kutumiza kwa mitsempha, kutulutsa magazi, komanso kuwongolera kayendedwe ka kugona ndi kudzuka. Imagwira ntchito pa ma receptor enaake, zomwe zimakhudza kugunda kwa mtima ndi kuyenda kwa magazi. Mwachipatala, adenosine imagwiritsidwa ntchito mu zamankhwala, makamaka pochiza matenda ena a mtima. Ntchito zake zambiri zikuwonetsa kufunika kwa adenosine pa thanzi komanso matenda.
-
Uridine 5-monophosphate, mchere wa disodium CAS:3387-36-8
Uridine 5-monophosphate, disodium salt (UMP) ndi nucleotide yomwe imagwira ntchito yofunika kwambiri pa kagayidwe ka maselo ndi kapangidwe ka RNA. UMP, yomwe ndi pyrimidine base uracil, shuga wa ribose, ndi gulu la phosphate, ndi yofunika kwambiri pa njira zosiyanasiyana zamoyo, kuphatikizapo kupanga ma nucleic acid ndikuwongolera njira za kagayidwe kachakudya. Mchere wa disodium umawonjezera kusungunuka kwake ndi kukhazikika kwake m'madzi amadzi, zomwe zimapangitsa kuti ukhale woyenera kafukufuku wa labotale komanso ntchito zochizira. UMP yatchuka chifukwa cha mphamvu zake zoteteza mitsempha ndi ubongo komanso zolimbikitsa kuzindikira, komanso ntchito yake yolimbikitsa thanzi la maselo onse.
-
Cytidine 5′-(disodium phosphate) CAS:6757-06-8
Cytidine 5′- (disodium phosphate) ndi chinthu chochokera ku nucleotide chomwe chimapangidwa ndi pyrimidine base cytosine, ribose shuga, ndi gulu la phosphate. Chomerachi chimagwira ntchito yofunika kwambiri m'njira zosiyanasiyana za biochemical, kuphatikizapo kupanga RNA, njira zowongolera, ndi ma signaling a ma cell. Mchere wa disodium umawonjezera kusungunuka kwake ndi kukhazikika kwake m'mikhalidwe ya thupi, zomwe zimapangitsa kuti ukhale woyenera kafukufuku wa labotale komanso kugwiritsa ntchito mankhwala. Cytidine 5′- (disodium phosphate) yapeza chidwi chifukwa chotenga nawo mbali mu kagayidwe ka nucleic acid ndi maubwino ake pakuwonjezera ntchito ya ubongo ndikuthandizira thanzi la ma cell.
-
5-Azacytidine CAS:320-67-2
5-Azacytidine ndi cytidine yopangidwa ndi nucleoside yomwe ili ndi atomu ya nayitrogeni pamalo 5 a mphete ya pyrimidine, m'malo mwa atomu ya kaboni. Kusintha kumeneku kumapereka mphamvu zapadera zamankhwala, zomwe zimapangitsa kuti ikhale chinthu chofunikira kwambiri mu biology ya mamolekyulu ndi chithandizo cha khansa. Monga choletsa champhamvu cha DNA methyltransferase, 5-azacytidine imatha kuyambitsanso majini otsekedwa mwa kusintha mawonekedwe a methylation ya DNA, motero imakhudza mawonekedwe a majini. Poyamba idapangidwa kuti ichite matenda a khansa ya m'magazi, 5-azacytidine yatchuka chifukwa cha ntchito zake zomwe zingagwiritsidwe ntchito mu epigenetic therapy, regenerative medicine, ndi kafukufuku wokhudzana ndi matenda osiyanasiyana omwe amadziwika ndi malamulo osazolowereka a majini.
-
2′-Fluoro-2′-deoxyuridine CAS:784-71-4
2′-Fluoro-2′-deoxyuridine (FdU) ndi analogue ya nucleoside ya deoxyuridine, komwe atomu ya hydrogen pamalo a 2′ a shuga wa ribose imalowedwa m'malo ndi atomu ya fluorine. Kusintha kumeneku kumawonjezera kukhazikika ndi ntchito ya bioactivity ya mankhwalawo, zomwe zimapangitsa kuti ikhale yofunikira pakufufuza zamankhwala ndi ntchito zochizira. FdU imadziwika kwambiri chifukwa cha ntchito yake ngati mankhwala oletsa mavairasi komanso khansa, chifukwa imatha kusokoneza kapangidwe ka DNA ndikuletsa kubwerezabwereza kwa mavairasi ena ndi maselo a khansa. Kapangidwe kake kapadera kamapangitsa kuti ikhale chida chofunikira kwambiri pakupanga njira zochiritsira komanso maphunziro a biology ya molecular.
-
![4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT260.png)
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one ndi analog yovuta ya nucleoside yomwe ili ndi maziko a pyrimidine olumikizidwa ndi shuga wosinthidwa wa ribose. Kupezeka kwa atomu ya fluorine ndi magulu a hydroxyl m'mapangidwe ake kumawonjezera mphamvu zake za biochemical, zomwe zimapangitsa kuti ikhale yosangalatsa pa kafukufuku wokhudza ma virus komanso khansa. Chomera ichi chingagwiritsidwe ntchito mu chemistry yamankhwala, makamaka ngati mankhwala ochizira omwe amayang'ana kapangidwe ka nucleic acid ndi njira za kagayidwe kachakudya m'zamoyo zoyambitsa matenda. Makhalidwe ake apadera a kapangidwe kake amalola kuyanjana bwino ndi zolinga zamoyo zomwe zimakhudzidwa ndi kagayidwe ka DNA ndi RNA.
-
1,3,5-tri-O-benzoyl-alpha-D-ribofuranose CAS:22224-41-5
1,3,5-Tri-O-benzoyl-alpha-D-ribofuranose ndi mtundu wa ribose wosinthidwa ndi mankhwala, wokhala ndi magulu atatu a benzoyloxy omwe amamangiriridwa ku malo a 1, 3, ndi 5 a kapangidwe ka ribofuranose. Kusintha kumeneku kumawonjezera kusungunuka kwake ndi kukhazikika kwake, zomwe zimapangitsa kuti ikhale yothandiza pa ntchito zosiyanasiyana zopangira mu organic chemistry ndi biochemistry. Monga chochokera ku ribose chotetezedwa, chimagwira ntchito ngati chothandizira pakupanga ma nucleosides ndi ma nucleotide, zigawo zofunika kwambiri za RNA ndi DNA. Kapangidwe kake kapadera kamapangitsa 1,3,5-tri-O-benzoyl-alpha-D-ribofuranose kukhala kofunikira kwa ofufuza omwe akufuna kupanga mankhwala atsopano ndi zida mu nucleotide chemistry.
-
2′-O-methyluridine CAS:2140-76-3
2′-O-Methyluridine ndi nucleoside yopangidwa mwachilengedwe momwe gulu la methyl limalumikizidwa ku atomu ya okosijeni ya malo a shuga wa ribose mu uridine. Kusintha kumeneku kumawonjezera kukhazikika ndi magwiridwe antchito a mamolekyu a RNA, zomwe zimapangitsa kuti ikhale gawo lofunikira kwambiri m'njira zosiyanasiyana zamoyo. 2′-O-Methyluridine imagwira ntchito yofunika kwambiri pa kapangidwe ndi ntchito ya ribonucleic acids (RNAs), kuphatikiza messenger RNA (mRNA) ndi transfer RNA (tRNA). Kupezeka kwake kumatha kusintha kukhazikika kwa RNA, kugwira ntchito bwino kwa kumasulira, komanso kuyanjana ndi mapuloteni ndi ma nucleic acid ena, zomwe zimapangitsa kuti ikhale chinthu chofunikira kwambiri pakuphunzira za biology ya mamolekyulu ndi ntchito zochiritsira.
-
adenosine 5′-monophosphate sodium*kuchokera ku yisiti CAS:4578-31-8
Adenosine 5′-monophosphate sodium (AMP) ndi nucleotide yochokera ku adenosine yomwe imagwira ntchito yofunika kwambiri mu kagayidwe ka maselo. AMP ndi yofunikira pa njira zosiyanasiyana zamoyo, kuphatikizapo kusamutsa mphamvu, kutumiza chizindikiro, komanso ngati choyambira cha kupanga ATP ndi ma nucleotide ena. Mtundu wa mchere wa sodium wa AMP ukhoza kutengedwa kuchokera ku yisiti, yomwe ili ndi ma nucleotide ambiri chifukwa cha njira zake zogwirira ntchito. Phala ili limagwiritsidwa ntchito kwambiri mu biochemistry ndi pharmacology ngati chothandizira cha biochemical, chowonjezera chakudya, komanso chowonjezera pazakudya, chifukwa cha ubwino wake wathanzi komanso ntchito zake polimbikitsa kagayidwe ka mphamvu.
-
2′-Deoxycytidine CAS:951-77-9
2′-Deoxycytidine ndi nucleoside yopangidwa ndi shuga wa deoxyribose ndi cytosine, yomwe imadziwika ndi kusakhalapo kwa gulu la hydroxyl pamalo a 2′ a ribose. Kusintha kumeneku kumapangitsa kuti ikhale gawo lofunikira la DNA, komwe imalumikizana ndi guanine panthawi yolumikizira maziko. 2′-Deoxycytidine imagwira ntchito yofunika kwambiri mu kagayidwe ka maselo ndi kapangidwe ka DNA, yomwe imagwira ntchito ngati chomangira cha deoxycytidine triphosphate (dCTP), yomwe ndi yofunika kwambiri pakubwerezabwereza ndi kukonza DNA. Kuphatikiza apo, nucleoside iyi ili ndi tanthauzo lofunikira mu kafukufuku wa biology ya molecular, chithandizo cha khansa, ndi njira zopewera ma virus, zomwe zikuwonetsa kufunika kwake mu kafukufuku woyambira komanso ntchito zachipatala.
-
2,2′-cyclouridine CAS:3736-77-4
2,2′-Cyclouridine ndi bicyclic nucleoside derivative ya uridine, yomwe imadziwika ndi kupangidwa kwa kapangidwe kake kapadera kozungulira komwe kumakhudza malo a 2′ ndi 2” a ribose moiety. Kusintha kwa kapangidwe kameneka kumapereka mawonekedwe osiyana a biochemical omwe amakhudza kukhazikika kwake ndi ntchito yake yachilengedwe. 2,2′-Cyclouridine yapeza chidwi mu biology ya mankhwala ndi chemistry yamankhwala chifukwa cha momwe ingagwiritsidwire ntchito ngati antiviral agent komanso mu kafukufuku wa RNA. Kutha kwake kusintha momwe ma nucleic acid amagwirira ntchito kumapangitsa kuti ikhale chida chofunikira pophunzira ubale wa kapangidwe ka RNA ndi ntchito zake, zomwe zingayambitse kupita patsogolo mu njira zochiritsira matenda opatsirana ndi mavairasi ndi matenda a majini.
-
2-Aminoadenosine CAS:2096-10-8
2-Aminoadenosine ndi chinthu chochokera ku adenosine chomwe chimapezeka mwachilengedwe, chomwe chimasiyanitsidwa ndi kukhalapo kwa gulu la amino pamalo awiri a shuga wa ribose. Kusintha kumeneku kumasintha kwambiri mawonekedwe ake a biochemical ndi ntchito zake, zomwe zimapangitsa kuti ikhale molekyulu yofunikira kwambiri m'njira zosiyanasiyana za thupi. 2-Aminoadenosine imagwira ntchito mu ma signaling a ma cell, kagayidwe kachakudya, ndi njira zowongolera, kuphatikiza zomwe zimakhudzana ndi homeostasis ya mphamvu ndi kufalikira kwa mitsempha. Kugwiritsa ntchito kwake kochiritsira kumatha kufalikira m'magawo angapo, kuphatikiza neurobiology ndi cardiology, komwe kungakhudze momwe ma cell amayankhira kupsinjika ndi kuvulala. Pamene kafukufuku akupitilira, 2-aminoadenosine ili ndi lonjezo lopanga mankhwala atsopano a bioactive ndi othandizira ochizira.
