Fmoc-Arg(Tos)-OH CAS:83792-47-6

Fmoc-Arg(Tos)-OH imagwira ntchito yofunika kwambiri pakupanga ma peptide, makamaka pamene chitetezo cholondola cha nayitrogeni ya guanidine mu arginine chikufunika. Gulu loteteza la Fmoc limateteza gulu la amino, kuonetsetsa kuti ma peptide amachitika nthawi yolumikizana, pomwe gulu la tosyl pa nayitrogeni ya guanidine limapereka chitetezo china. Ofufuza amagwiritsa ntchito Fmoc-Arg(Tos)-OH popanga ma peptide ndi kusintha kwa guanidine, zomwe zimakhudza zochita zawo zamoyo. Njira yotetezera iwiri imalola kusintha kwa guanidine, zomwe zimapangitsa kuti mankhwalawa akhale ofunika popanga ma peptide kuti aphunzire za maantibayotiki, bioconjugation, komanso mankhwala. Kugwirizana kwa Fmoc-Arg(Tos)-OH ndi njira zodziwika bwino zopangira ma peptide, kuphatikiza solid-phase peptide synthesis (SPPS), kumawonjezera phindu lake. Kapangidwe kameneka kamagwiritsidwa ntchito popanga ma peptide kuti ayesedwe pazamoyo, kupeza mankhwala, komanso kupanga zinthu zopangidwa ndi ma peptide. Kuchotsa magulu oteteza kumalola kuti arginine iphatikizidwe bwino ndi guanidine yosinthidwa, zomwe zimathandiza kuti ma peptide osiyanasiyana apangidwe. Mwachidule, Fmoc-Arg(Tos)-OH ndi chida chapadera komanso chosiyanasiyana mu peptide chemistry, chomwe chimapatsa mphamvu ofufuza kuti afufuze ndikusintha momwe guanidine imagwirira ntchito pazasayansi ndi machiritso osiyanasiyana.