Fmoc-D-Asn(Trt)-OH CAS:180570-71-2

Fmoc-D-Asn(Trt)-OH ndi yofunika kwambiri popanga ma peptide, makamaka popanga ma peptide okhala ndi D-enantiomer ya asparagine molondola. Gulu loteteza la Fmoc limateteza gulu la amino, kuonetsetsa kuti pali zochita zosiyanasiyana panthawi yolumikizana kwa peptide, pomwe gulu la trityl limawonjezera chitetezo china. Ofufuza amagwiritsa ntchito Fmoc-D-Asn(Trt)-OH kwambiri popanga ma peptide osiyanasiyana, kuphatikiza kupanga mankhwala, zinthu zachilengedwe, komanso kupanga ma peptide ogwira ntchito omwe ali ndi mawonekedwe enaake a stereochemical. Kugwirizana kwake ndi njira zodziwika bwino zopangira ma peptide, mu njira zonse ziwiri zokhazikika komanso zothetsera mavuto, kumawonjezera kusinthasintha kwake muzochita zosiyanasiyana zofufuzira. Kuchotsa magulu oteteza kumalola kuti D-asparagine iphatikizidwe m'njira za peptide, ndikukulitsa mndandanda wa ma peptide opangidwa. Kuphatikiza apo, Fmoc-D-Asn(Trt)-OH imagwiritsa ntchito popanga ma peptide ofufuza ma proteomics ndikuphunzira njira zamaselo. Kugwiritsa ntchito bwino gulu loteteza trityl kumathandiza kuti D-asparagine igwire bwino ntchito, zomwe zimapatsa ofufuza chida chofunikira popanga ma peptide okhala ndi zosintha zomwe zakonzedwa. Mwachidule, Fmoc-D-Asn(Trt)-OH ndi chida chogwiritsidwa ntchito mosiyanasiyana komanso chofunikira kwambiri mu peptide chemistry, zomwe zimapatsa ofufuza mphamvu zofufuzira ndikusintha D-asparagine reaction pazinthu zosiyanasiyana zasayansi, makamaka kuyang'ana kwambiri ma peptide okhala ndi D-amino acid.