Fmoc-D-Cys(Trt)-OH CAS:167015-11-4

Fmoc-D-Cys (Trt)-OH imagwira ntchito ngati chida choyambira popanga ma peptide, makamaka popanga ma peptide okhala ndi D-enantiomer ya cysteine ​​​​mwanzeru. Gulu loteteza la Fmoc limateteza gulu la amino, kuonetsetsa kuti pali zochita zosiyanasiyana panthawi yolumikizana ndi peptide, pomwe gulu la trityl limawonjezera chitetezo china ku gulu la thiol. Ofufuza amagwiritsa ntchito kwambiri Fmoc-D-Cys (Trt)-OH popanga ma peptide pazinthu zosiyanasiyana, kuphatikiza kupanga mankhwala ochiritsira ozikidwa pa peptide, zinthu zachilengedwe, ndi ma peptide okhala ndi mapangidwe enaake. Kugwirizana kwake ndi njira zodziwika bwino zopangira ma peptide, mu njira zonse ziwiri zokhazikika komanso zothetsera mavuto, kumawonjezera kusinthasintha kwake muzochita zosiyanasiyana zofufuzira. Kuchotsa magulu oteteza kumalola kuyika D-cysteine ​​​​m'njira za peptide, kukulitsa kuchuluka kwa ma peptide opangidwa. Kuphatikiza apo, Fmoc-D-Cys (Trt)-OH ikupeza phindu mu maphunziro okhudzana ndi uinjiniya wa mapuloteni, kapangidwe ka disulfide bond, ndi machitidwe a peptide conjugation. Kugwiritsa ntchito bwino gulu loteteza trityl kumathandiza kusintha molondola momwe D-cysteine ​​​​ikuchitira, zomwe zimapatsa ofufuza chida chofunikira popanga ma peptide okhala ndi zosintha zomwe zakonzedwa. Mwachidule, Fmoc-D-Cys (Trt)-OH ndi chida chogwiritsidwa ntchito mosiyanasiyana komanso chofunikira kwambiri mu peptide chemistry, zomwe zimapatsa ofufuza mphamvu zofufuzira ndikusintha momwe D-cysteine ​​​​ikuchitira pazinthu zosiyanasiyana zasayansi, makamaka kuyang'ana kwambiri ma peptide omwe ali ndi amino acid yofunika kwambiri mu D-configuration.