Leflunomide CAS: 75706-12-6 Wopanga Wopanga

Leflunomide sikugwira ntchito, koma teriflunomide imalepheretsa kaphatikizidwe ka pyrimidine de novo pa mlingo wochepa wochizira mwa kuletsa dihydroorotate dehydrogenase (enzyme yodziwira mlingo wa kaphatikizidwe ka UMP), kuchepetsa kaphatikizidwe ka DNA ndi RNA, ndikuletsa kufalikira kwa maselo ndi kupanga ma antibodies.Kuchepetsa kwa dihydroorotate kukhala orotate kumachitika nthawi imodzi ndi kuchepetsedwa kwa cofactor yake, ubiquinone (coenzyme Q).Kuletsa kwa dihydroorotate dehydrogenase ndi teriflunomide kumawonetsa ma kinetics opanda mpikisano komanso osapikisana.Kulamulira kwa leflunomide kwa odwala omwe ali ndi nyamakazi ya nyamakazi kumapangitsa kuti pang'onopang'ono kuchotsedwe kwa maselo a B ndi kuchepetsa mphamvu ya chitetezo cha mthupi.