Candesartana Cilexetila CAS:145040-37-5

Candesartan cilexetil ndi mankhwala amphamvu, okhalitsa, komanso osankha angiotensin II mtundu wa 1 receptor AT1 antagonist, candesartan.Imasinthidwa mwachangu kukhala candesartan panthawi yoyamwa m'mimba.Pambuyo pa hydrolysis ya candesartan cilexetil kupita ku candesartan pa mayamwidwe a m'mimba, candesartan mosankha amapikisana ndi angiotensin II kuti amange angiotensin II receptor subtype 1 AT1 mumitsempha yosalala, kutsekereza angiotensin II-mkhalapakati vasoconstriction ndi kuchititsa vasodilatation.Kuphatikiza apo, kutsutsa kwa AT1 mu adrenal gland kumalepheretsa kaphatikizidwe ka aldosterone ka angiotensin II ndi kutulutsidwa ndi adrenal cortex;Kuchuluka kwa sodium ndi madzi kumawonjezeka, kutsatiridwa ndi kuchepa kwa voliyumu ya plasma ndi kuthamanga kwa magazi.