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N-Acetyl-D-Glucosamine CAS: 7512-17-6 Wopanga Wogulitsa
N-Acetyl-D-Glucosamine ndi chinthu chochokera ku N-acetyl chomwe chimachokera ku glucosamine. Mwa mankhwala, ndi amide pakati pa glucosamine ndi acetic acid. Gawo limodzi la N-acetylglucosamine lomwe limalumikizidwa ndi zotsalira za serine kapena threonine pa mapuloteni a nyukiliya ndi cytoplasmic -O-GlcNAc, ndi kusintha kwa mapuloteni komwe kumachitika pambuyo pa kusinthika. Mapuloteni osinthidwa a O-GlcNAc amakhudzidwa pozindikira momwe michere ilili m'malo ozungulira maselo ndikusintha momwe mapuloteni amagwirira ntchito moyenera. O-GlcNAc imayang'anira mayankho a maselo ku mahomoni monga insulin, imayambitsa yankho loteteza ku kupsinjika, imasintha mphamvu ya selo kukula ndikugawa, ndikulamulira kulembedwa kwa majini. Mwa anthu, imapezeka pakhungu, cartilage ndi mtsempha wamagazi ngati gawo la hyaluronic acid, ndi minofu ya mafupa, cornea ndi aorta ngati gawo la keratan sulfate.
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Creatine Pyruvate CAS: 55965-97-4 Wopanga Wopanga
Creatine Pyruvate ndi mankhwala omwe ali ndi Creatine ndi pyruvic acid ndipo amagwiritsidwa ntchito ndi opanga thupi ngati chowonjezera kuti apeze zotsatira zoyambitsa matenda ndipo amasungunuka kwathunthu m'madzi. Mu mawonekedwe ake ophatikizika, Creatine Pyruvate imasungunuka nthawi 10 kuposa momwe imakhalira payokha. Kafukufuku wazachipatala wasonyeza kuti Pyruvate imachepetsa mafuta m'thupi popanda kukhudza mapuloteni a minofu, chinthu chofunikira kwambiri pakukwaniritsa minofu yowonda. Zowonjezera za Creatine Pyruvate ndi chithandizo chabwino kwambiri cha zakudya kwa othamanga omwe akufuna kukulitsa mphamvu ya minofu ndi kupirira pamapulogalamu olimbitsa thupi amphamvu.
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Vitamini A Palmitat CAS: 79-81-2 Wopanga Wogulitsa
Retinyl palmitate ndi m'gulu la mankhwala otchedwa retinoids, omwe ali ngati vitamini A m'mankhwala. Amathandiza kwambiri pa masomphenya, khungu ndi chitetezo chamthupi, amaletsa kuchulukana kwa maselo komanso amaletsa khansa. Ndi chakudya chofunikira komanso mankhwala ochiritsira. All-trans-retinyl palmitate ndi all-trans-retinyl ester yomwe imapezeka mwa kusungunuka kwa gulu la carboxy la palmitic (hexadecanoic acid) ndi gulu la hydroxy la all-trans-retinol. Amagwiritsidwa ntchito mu zodzoladzola pochiza matenda osiyanasiyana a pakhungu monga ziphuphu, ukalamba wa khungu, makwinya, mawanga akuda, komanso kuteteza ku psoriasis. Ili ndi gawo ngati metabolite ya Escherichia coli, metabolite ya xenobiotic ya anthu komanso antioxidant. Ndi retinyl palmitate ndi all-trans-retinyl ester. Imagwira ntchito mogwirizana ndi all-trans-retinol.
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Benfotiamine CAS:22457-89-2 Wopanga Wogulitsa
S-Benzoylthiamine O-monophosphate (Benfotiamine) ndi chinthu chochokera ku S-acyl thiamine chomwe chimachokera ku amphiphilic. Ndi vitamini wosungunuka ndi mafuta. Benfotiamine ili ndi mphete ya thiazole. Benfotiamine imapezeka kwambiri kuposa thiamine.
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Kolajeni Hydrolyzed CAS: 92113-31-0 Wopanga Wogulitsa
Kolajeni ya hydrolyzed imatchedwanso hydrolyzed collagen. Kolajeni ya hydrolyzed ndi mtundu watsopano wa chinthu cha collagen, chomwe chimapangidwa kuchokera ku collagen kapena zinthu zambiri za collagen. Kuwonjezera pa kapangidwe ka amino acid ka collagen (pafupifupi 30% ya zotsalira zonse za amino acid ndi glycine), ilinso ndi 15-30% ya ma amino acid awiri omwe sapezeka kawirikawiri m'mapuloteni ena, proline ndi 4-hydroxyproline Kuwonjezera pa asidi), ilinso ndi makhalidwe a kulemera kochepa kwa mamolekyulu, ndipo kapangidwe kake kamakhala ndi ma peptide ang'onoang'ono okhala ndi kulemera kwa mamolekyulu osakwana 3000.
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Vitamini E Yachilengedwe CAS: 59-02-9 Wopanga Wogulitsa
Mafuta a Vitamini E ndi vitamini wosungunuka ndi mafuta, wotchedwanso tocopherol. Ndi imodzi mwa ma antioxidants ofunikira kwambiri. Ndi zinthu zosungunulira mafuta monga ethanol, ndipo sizisungunuka m'madzi, kutentha, asidi wokhazikika, base-labile. Ndi womasuka ndi mpweya koma samasuka ndi kutentha. Ndipo ntchito ya vitamini E inali yotsika kwambiri pakukazinga. α-Tocopherol imapangidwa kuchokera ku γ-tocopherol pogwiritsa ntchito enzyme γ-tocopherol methyltransferase. Ndi mtundu waukulu wa Vitamini E m'magazi a anthu. Imapezeka mu mafuta a mbewu ya mpendadzuwa.
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Curcumin (turmeric) 95% CAS:458-37-7 Wogulitsa Wopanga
Curcumin ndiye mtundu waukulu wachikasu mu turmeric ndi curry ndipo uli ndi ntchito zotsutsana ndi antioxidant, anti-inflammatory, komanso antitumor. Imaletsa kupanga nitric oxide (NO) (IC50 = 6 μM) ndipo imachepetsa ntchito ya nitric oxide synthase (iNOS) mu maselo a RAW 264.7 omwe amalimbikitsidwa ndi LPS. Curcumin imaletsa kutulutsidwa kwa histamine ndi ma cytokines otupa a TNF-α, IL-1β, IL-6, ndi IL-8 kuchokera ku maselo a HMC-1 mast. Mu thupi, curcumin imachepetsa kuchuluka kwa histamine ndi TNF-α mu seramu, imaletsa kusintha kwa histopathological kwa mucosa wa m'mphuno, komanso imachepetsa kuchuluka kwa kuyetsemula ndi kukanda m'mphuno mu chitsanzo cha mbewa cha ovalbumin-induced rhinitis.
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Vitamini B1 (Thiamine Hydrochloride) CAS: 67-03-8 Wopanga Wogulitsa
Thiamine Hydrochloride ndi mchere wa thiamine (vitamini B1), vitamini wofunikira pa kagayidwe kachakudya m'thupi, kukula kwa maselo, kufalitsa kwa mitsempha ndi kupanga acetylcholine. Vitamini B1 imathandiza kupewa mavuto osiyanasiyana azaumoyo kuphatikizapo kuwonongeka kwa mtima.
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Hydroxycobalamin HCL CAS:78091-12-0 Wopanga Wogulitsa
Hydroxycobalamin (ohcbl, kapena B12a) ndi mtundu wachilengedwe wa vitamini B12, kapena gulu limodzi la vitamini B12. Ndi membala wofunikira wa gulu la cobalamine. Mabakiteriya ambiri omwe amapanga mavitamini amapanga vitamini B12 m'mabizinesi mu mawonekedwe a hydroxycobalamin. Hydroxycobalamin ndi yofiira kwambiri. Vitamini B12 m'thupi la munthu nthawi zambiri simapezeka mu mawonekedwe a hydroxycobalamin. Komabe, mwa anthu, hydroxycobalamin imasinthidwa mosavuta kukhala mtundu wothandiza wa coenzyme wa vitamini B12. Mankhwala a hydroxycobalamin ndi jakisoni wake wosabala, womwe umagwiritsidwa ntchito pochiza kusowa kwa vitamini ndi poizoni wa cyanide (chifukwa umagwirizana ndi ma ioni a cyanide).
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Kolajeni II CAS:9064-67-9 Wopanga Wogulitsa
Collagen ndiye chinthu chachikulu kwambiri chomwe chili ndi mapuloteni ambiri okhala ndi ulusi m'thupi lonse. Amapezeka kwambiri m'maselo a ulusi monga khungu, ligament ndi tendon mu mawonekedwe a ulusi wautali ndipo amapezekanso m'ma cornea, mitsempha yamagazi, mafupa, cartilage, intervertebral disc ndi m'matumbo. Awa ndi mapuloteni ambiri m'zinyama zomwe zimapanga 30% ya mapuloteni onse m'thupi la nyama.
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Nicotinamide Riboside (Chloride) CAS:23111-00-4 Wopanga Wogulitsa
Nicotinamide Riboside Chloride ndi mchere wa chloride womwe umapezeka mu nicotinamide riboside (NR).NR ndi mtundu watsopano wa pyridine-nucleoside wa vitamini B3 womwe umagwira ntchito ngati choyambira cha nicotinamide adenine dinucleotide (NAD) kapena NAD+. Nicotinamide riboside chloride ndi mtundu wa kristalo wa Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride imawonjezera milingo ya NAD[+] ndikuyambitsa SIRT1 ndi SIRT3, zomwe zimapangitsa kuti kagayidwe ka okosijeni kachuluke komanso kuteteza ku zovuta za kagayidwe kachakudya zomwe zimayambitsidwa ndi mafuta ambiri. Nicotinamide riboside chloride imagwiritsidwa ntchito muzakudya zowonjezera.
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D-Fructose 1,6-Disphosphate Trisodium Salt CAS:38099-82-0
Fructose-1,6-biphosphate (F1,6P) ndi glycolytic intermediate yomwe imapangidwa ndi kusamutsa phosphate kuchokera ku ATP kupita ku fructose-6-phosphate ndi enzyme phosphofructokinase. Fructose-1,6-biphosphate, pamodzi ndi fructose-2,6-biphosphate, imasintha ntchito ya phosphofructokinase-1 (PFK-1), gawo loletsa kuchuluka kwa shuga m'magazi. Panthawi ya glycolysis, aldolase imagawa Fructose-1,6-biphosphate kukhala dihydroxacetone phosphate (DHAP) ndi glyceraldehyde phosphate. Fructose-1,6-biphosphate ndi allosteric activator ya M2 isoform ya Pyruvate Kinase (PK-M2), mtundu waukulu wa pyruvate kinase m'maselo a khansa.
