-
Amylase, a-, Aspergillus oryzae CAS:9001-19-8 Mtengo wa Wopanga
AmYlase ndi enzyme yomwe imathandizira kugawikana kwa starch kukhala shuga wosavuta monga maltose ndi shuga. Nthawi zambiri imapangidwa ndi zamoyo zosiyanasiyana, kuphatikizapo mabakiteriya, bowa, ndi zomera.
Mawu akuti “a-” mu “a-amylase” amatanthauza mtundu wa amylase womwe umathira madzi m'magawo amkati mwa alpha-1,4 glycosidic mkati mwa molekyulu ya starch. Izi zimapangitsa kuti pakhale ma polysaccharides afupiafupi, omwe amatha kugawidwanso kukhala shuga ndi ma enzyme ena a amylase.
Aspergillus oryzae ndi mtundu wa bowa wopangidwa ndi ulusi wodziwika bwino chifukwa cha kuthekera kwake kupanga amylase yambiri. Amagwiritsidwa ntchito kwambiri popanga ma enzyme a mafakitale chifukwa cha mphamvu yake ya amylolytic. Ma enzyme opangidwa ndi Aspergillus oryzae, kuphatikizapo a-amylase, amagwiritsidwa ntchito kwambiri m'mafakitale osiyanasiyana, monga chakudya, kupanga mowa, nsalu, ndi sopo.
Mu makampani opanga chakudya, a-amylase yochokera ku Aspergillus oryzae nthawi zambiri imagwiritsidwa ntchito pophika, kupanga mowa, ndi kukonza sitachi. Imathandiza kuswa sitachi mu mtanda, chimanga, ndi zinthu zina zopangira, zomwe zimathandiza kusintha ma carbohydrate ovuta kukhala shuga wosavuta womwe ungasinthidwe ndi yisiti kapena mabakiteriya panthawi yophika. Enzyme iyi imagwiritsidwanso ntchito popanga nsalu kuti ithandize kuchotsa zinthu zopangira sitachi kuchokera ku nsalu.
-
Aprotinin CAS:9087-70-1 Mtengo wa Wopanga
Aprotinin ndi mankhwala achilengedwe oletsa ma enzyme osiyanasiyana a proteolytic, kuphatikizapo trypsin, chymotrypsin, ndi plasmin. Amagwiritsidwa ntchito kwambiri m'malo azachipatala, makamaka pa opaleshoni ya mtima, kuti achepetse kutuluka magazi ndikuchepetsa kutaya magazi. Aprotinin imagwira ntchito poletsa ntchito ya ma enzyme awa, omwe amakhudzidwa ndi kusweka kwa magazi ndi kuwonongeka kwa fibrin, puloteni yomwe imathandiza kupanga magazi. Mwa kupewa kuchuluka kwa ma enzyme, aprotinin imathandiza kusunga kukhazikika kwa magazi, potero kuchepetsa mavuto otuluka magazi panthawi ya opaleshoni.
-
Thrombin CAS:9002-04-4 Mtengo wa Wopanga
Thrombin ndi enzyme yofunika kwambiri yomwe imagwira ntchito polimbitsa magazi, yomwe imadziwikanso kuti coagulation. Imapangidwa kuchokera ku puloteni yake yoyambirira, prothrombin, poyankha kuvulala kapena kuwonongeka kwa mitsempha yamagazi. Thrombin imagwira ntchito yofunika kwambiri popanga magazi kuundana, zomwe zimathandiza kupewa kutuluka magazi kwambiri ndikulimbikitsa kuchira kwa mabala.
Akayamba kugwira ntchito, thrombin imasintha fibrinogen, puloteni ina m'magazi, kukhala fibrin. Fibrin imapanga kapangidwe konga mesh komwe kamasunga ma platelet ndi maselo ofiira a magazi, ndikupanga magazi oundana okhazikika. Thrombin imayambitsanso zinthu zina zotsekeka, zomwe zimawonjezera njira yotsekeka kwa magazi.
Kupatula ntchito yake pakupanga magazi kuundana, thrombin ili ndi ntchito zina zofunika. Imathandizira kuchira kwa mabala mwa kulimbikitsa kusamuka ndi kuchulukana kwa maselo omwe amagwira ntchito yokonzanso minofu. Thrombin imagwiranso ntchito ngati vasoconstrictor, zomwe zimapangitsa kuti mitsempha yamagazi ichepetse ndikuchepetsa kuyenda kwa magazi kupita kumalo ovulala.
-
Urease CAS: 9002-13-5 Mtengo wa Wopanga
Urease ndi enzyme yomwe imayambitsa hydrolysis ya urea kukhala ammonia ndi carbon dioxide. Imapangidwa ndi tizilombo toyambitsa matenda osiyanasiyana, kuphatikizapo mabakiteriya, bowa, ndi zomera. Urease ndi wofunikira kwambiri pa kagayidwe ka nayitrogeni ndipo umagwira ntchito yofunika kwambiri pazochitika zosiyanasiyana zamoyo, monga hydrolysis ya urea mu impso ndi nitrogen assimilation mu zomera. Imagwiranso ntchito m'mafakitale, kuphatikizapo kuzindikira mabakiteriya opanga urea, feteleza wochokera ku urea, komanso kuzindikira zoletsa za urea pochiza matenda ena.
-
Leupeptin hemisulfate CAS:103476-89-7
Leupeptin hemisulfate ndi mankhwala oletsa protease omwe amagwiritsidwa ntchito kwambiri mu kafukufuku wa biochemical ndi biomedical. Amachokera ku mabakiteriya a Streptomyces ndipo amagwira ntchito poletsa ntchito ya ma protease osiyanasiyana, kuphatikizapo trypsin, chymotrypsin, ndi plasmin.
Leupeptin hemisulfate nthawi zambiri imagwiritsidwa ntchito mu zoyeserera za mu labotale kuti apewe kuwonongeka kwa mapuloteni osafunikira, chifukwa ma protease amatha kuwononga mapuloteni ndi ma peptide, zomwe zimakhudza zotsatira za zoyeserera. Mwa kuletsa ntchito ya protease, leupeptin hemisulfate imathandiza kukhazikika kwa mapuloteni ndikusunga umphumphu wawo panthawi yoyeserera.
Kuphatikiza apo, leupeptin hemisulfate yagwiritsidwa ntchito mu maphunziro a chikhalidwe cha maselo kuti ifufuze ntchito za ma protease m'njira zosiyanasiyana zamaselo, monga kuzindikiritsa maselo, apoptosis, ndi kusintha kwa mapuloteni.
-
Lipase kuchokera ku kapamba wa nkhumba CAS:9001-62-1
Lipase ndi enzyme yomwe imayambitsa hydrolysis ya lipids, makamaka kugawanika kwa triglycerides kukhala mafuta acids ndi glycerol. Imapangidwa ndi zamoyo zosiyanasiyana, kuphatikizapo nyama, zomera, ndi tizilombo toyambitsa matenda. Lipase imagwira ntchito yofunika kwambiri pakugaya chakudya, chifukwa imathandizira kugawanika ndi kuyamwa mafuta m'matumbo ang'onoang'ono. Kuphatikiza apo, lipase imagwiritsidwa ntchito kwambiri m'mafakitale monga kukonza chakudya, kupanga sopo, mankhwala, ndi kupanga biofuel. Kutha kwake kugawanika lipids kumapangitsa kuti ikhale yothandiza pa ntchito monga kusintha lipids, kuwonjezera kukoma, komanso kuchotsa mafuta.
-
Lysostaphin CAS:9011-93-2 Mtengo wa Wopanga
Lysostaphin ndi enzyme yamphamvu yolimbana ndi mavairasi yomwe imalimbana ndi kupha Staphylococcus aureus, bakiteriya yomwe imayambitsa matenda osiyanasiyana mwa anthu. Imachokera ku bakiteriya ya Staphylococcus simulans ndipo imatha kugwetsa khoma la maselo a S. aureus, zomwe zimapangitsa kuti iwonongeke.
Enzymeyi imayang'ana makamaka gawo la peptidoglycan la khoma la maselo a bakiteriya, kusokoneza kapangidwe kake ndikuyambitsa lysis ya bakiteriya. Njira yapaderayi yogwirira ntchito imapangitsa lysostaphin kukhala yothandiza kwambiri polimbana ndi mitundu ya S. aureus, kuphatikizapo yomwe imakana maantibayotiki omwe amagwiritsidwa ntchito nthawi zambiri.
-
L-Lactate dehydrogenase CAS:9001-60-9
L-Lactate dehydrogenase (LDH) ndi enzyme yomwe imagwira ntchito yofunika kwambiri pa kagayidwe ka mphamvu zamaselo, makamaka pakusintha kwa pyruvate kukhala lactate. Imalimbikitsa kusintha kosinthika kwa L-lactate kukhala pyruvate, pogwiritsa ntchito NAD+ ngati cofactor.
LDH imapezeka m'maselo osiyanasiyana a thupi, kuphatikizapo chiwindi, mtima, minofu, ndi maselo ofiira a magazi. Kuchuluka kwa ntchito yake kungagwiritsidwe ntchito ngati chizindikiro cha matenda ena, monga kuwonongeka kwa chiwindi, matenda a mtima, ndi mitundu ina ya khansa.
Ntchito yaikulu ya LDH ndikusunga mphamvu ya maselo mwa kuthandizira kusintha kwa pyruvate, chinthu chopangidwa ndi glycolysis, kukhala lactate. Njirayi, yomwe imadziwika kuti anaerobic glycolysis, imachitika popanda mpweya ndipo imalola maselo kupitiliza kupanga mphamvu pamene mpweya uli wochepa.
-
Pepsin CAS:9001-76-7 Mtengo wa Wopanga
Pepsin ndi enzyme yogaya chakudya yomwe imapezeka m'mimba yomwe imagwira ntchito yofunika kwambiri pakugaya ndi kuphwanya mapuloteni. Ili m'gulu la ma enzyme otchedwa proteases, omwe amachititsa kugawa mapuloteni kukhala ma peptide ang'onoang'ono ndi ma amino acid, zomwe zimapangitsa kuti alowe m'matumbo ang'onoang'ono.
Pepsin imapangidwa ndi kutulutsidwa ndi maselo omwe ali m'mimba, omwe amadziwika kuti maselo akuluakulu, mu mawonekedwe osagwira ntchito otchedwa pepsinogen. Chakudya chikalowa m'mimba, chimayambitsa kutulutsidwa kwa asidi m'mimba, zomwe zimasintha pepsinogen kukhala mawonekedwe ake ogwira ntchito, pepsin. Pepsin imagwira ntchito bwino kwambiri m'malo okhala ndi asidi, chifukwa pH yotsika m'mimba imathandiza kuyambitsa ndikusunga ntchito yake ya enzymatic.
-
Mapuloteni Kinase Supplement KT5823 CAS:126643-37-6
Chowonjezera cha protein kinase KT5823 ndi choletsa chaching'ono cha molekyulu chomwe chimalimbana ndikuletsa ntchito ya protein kinase. Ma protein kinase ndi ma enzyme omwe amafosforasitsa mapuloteni powonjezera magulu a phosphate ku ma amino acid residues enaake, makamaka serine, threonine, kapena tyrosine. Njira yofosforasitsa imeneyi imagwira ntchito yofunika kwambiri m'njira zosiyanasiyana zolumikizirana ndi maselo, kuwongolera magwiridwe antchito a mapuloteni, komanso kuwongolera njira zamaselo monga kukula kwa maselo, kugawikana, kusiyanitsa, ndi apoptosis.
KT5823 imagwiritsidwa ntchito kwambiri mu kafukufuku kuti ifufuze momwe mapuloteni a protein kinases amagwirira ntchito komanso njira zolumikizirana. Mwa kuletsa mapuloteni a protein kinases, KT5823 ingathandize ofufuza kudziwa mapuloteni ndi njira zomwe zimakhudzidwa ndi ntchito ya kinase. Chidziwitsochi chingathandize kumvetsetsa ntchito ya mapuloteni a protein kinases m'maselo ndi kuzindikira zolinga zatsopano zochiritsira.
-
Pyridoxal-5′-phosphate monohydrate CAS:41468-25-1
Pyridoxal-5′-phosphate monohydrate, yomwe imadziwikanso kuti PLP, ndi mtundu wogwira ntchito wa vitamini B6. Ndi coenzyme yofunika kwambiri yomwe imakhudzidwa ndi zochita zosiyanasiyana za enzymatic m'thupi. PLP imagwira ntchito yofunika kwambiri pa kagayidwe ka amino acid, kupanga ma neurotransmitter, komanso kupanga heme, yomwe ndi gawo la hemoglobin.
PLP imagwira ntchito ngati coenzyme polumikizana ndi ma enzyme enaake ndikuthandizira machitidwe a mankhwala. Imagwira ntchito ngati chothandizira, kuthandizira kusintha kwa zinthu zosiyanasiyana, monga ma amino acid, kukhala zinthu zosiyanasiyana. PLP ndi yofunika kwambiri pa kagayidwe ka amino acid, monga kusintha kwa tryptophan kukhala serotonin, kapena kugawika kwa glycine kukhala serine.
Kuwonjezera pa ntchito yake mu kagayidwe ka amino acid, PLP imagwiranso ntchito popanga ma neurotransmitters monga dopamine, norepinephrine, ndi gamma-aminobutyric acid (GABA). Ma neurotransmitters amenewa ndi ofunikira pakugwira ntchito bwino kwa ubongo ndipo amagwira ntchito yolamulira malingaliro, kuzindikira, komanso kutumiza zizindikiro pakati pa maselo amitsempha.
Kuphatikiza apo, PLP ndi yofunikira popanga heme, gawo la hemoglobin lomwe limapezeka m'maselo ofiira a magazi. Hemoglobin imayang'anira kunyamula mpweya m'thupi lonse, zomwe zimapangitsa PLP kukhala yofunika kwambiri kuti mpweya ukhale wabwinobwino komanso kuonetsetsa kuti ziwalo ndi minofu zosiyanasiyana zikugwira ntchito bwino.
Chifukwa cha kufunika kwake m'njira zambiri za biochemical, nthawi zina PLP supplementation imalimbikitsidwa kwa anthu omwe ali ndi matenda enaake kapena zofooka zomwe zimakhudza kagayidwe ka vitamini B6. Imapezeka mu mawonekedwe a supplement ndipo imatha kuperekedwa ndi opereka chithandizo chamankhwala pazosowa zinazake.
-
Reductase, glutathione CAS:9001-48-3
Glutathione reductase ndi enzyme yomwe imagwira ntchito yofunika kwambiri pakusunga bwino kwa glutathione yochepetsedwa komanso yosungunuka (GSH/GSSG) m'maselo. Glutathione ndi tripeptide yopangidwa ndi amino acids glycine, cysteine, ndi glutamate. Imagwira ntchito ngati antioxidant yayikulu ya maselo ndipo imagwira ntchito zosiyanasiyana m'maselo, kuphatikizapo kuchotsa poizoni m'thupi, kupanga ndi kukonza DNA, komanso kupanga mapuloteni.
Glutathione reductase imalimbikitsa kuchepetsa oxidized glutathione (GSSG) kukhala yochepetsedwa (GSH) pogwiritsa ntchito NADPH (nicotinamide adenine dinucleotide phosphate) ngati cofactor. Izi ndizofunikira kwambiri kuti glutathione ikhale yocheperako m'maselo, chifukwa GSSG imatha kudziunjikira pakakhala kupsinjika kwa okosijeni.
Mwa kusunga chiŵerengero choyenera cha GSH ku GSSG, glutathione reductase imathandiza kuteteza maselo ku kuwonongeka kwa okosijeni komwe kumachitika chifukwa cha mitundu ya okosijeni yogwira ntchito (ROS) ndi mamolekyu ena owopsa. Imagwira ntchito yofunika kwambiri mu chitetezo cha ma cell cha antioxidant.
Kuphatikiza apo, glutathione reductase imagwiranso ntchito pobwezeretsanso glutathione disulfide (GSSG) yomwe imapangidwa panthawi ya kagayidwe kachakudya, kuonetsetsa kuti glutathione (GSH) yochepetsedwa ikupezeka pa ntchito zake zambiri zamaselo.
